Deciphering sex differences in the immune system and depression

Frontiers in Neuroendocrinology
Jennifer R RainvilleGeorgia E Hodes

Abstract

Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribution of gonadal and stress hormones to immune function at the cellular and molecular level in the brain and body. We propose hormonal and genetic sex specific immune mechanisms that may contribute to the etiology of mood disorders.

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Citations

Jun 20, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Marie-Julie AllardGuillaume Sebire
Nov 30, 2019·Alcoholism, Clinical and Experimental Research·A Leslie MorrowPatrizia Porcu
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Apr 18, 2019·International Journal of Molecular Sciences·Natalia LesiewskaMaciej Bieliński
Sep 13, 2020·Journal of Neuroscience Research·Kristina K DeonaraineJun Wang
Jul 22, 2019·Frontiers in Neuroendocrinology·Mariya TsyglakovaGeorgia E Hodes
Feb 14, 2021·Translational Psychiatry·Anouk E de WitRobert A Schoevers
Apr 2, 2021·Frontiers in Cellular and Infection Microbiology·Mariana Guilger-CasagrandeRenata Lima
Jul 14, 2021·Pain·Ann M GregusMatthew W Buczynski

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