Deciphering signaling pathways in clinical tissues for personalized medicine using protein microarrays

Journal of Cellular Physiology
Katharina MalinowskyKarl-Friedrich Becker

Abstract

The current transition in cancer therapy from general treatment approaches, based mainly on chemotherapy and radiotherapy, to more directed approaches that aim to inhibit specific molecular targets has brought about new challenges for pathology. In the past, classical assignment of pathology consisted of tumor diagnosis and staging for further therapy decisions; nowadays, pathologists are asked to predict possible therapeutic results by detecting and quantifying therapeutic targets in tumors such as the human epidermal growth factor receptor 2 (HER2). The best approach to analyze such molecular targets is to provide a tumor-specific protein expression profile prior to therapy. To further elucidate signaling networks underlying cancer development and to identify new targets, it is necessary to implement tools that allow fast, precise, cheap, and simultaneous analysis of many network components while requiring only a small amount of clinical material. Reverse phase protein microarray (RPPA) is a promising technology that meets these requirements while enabling quantitative measurement of proteins. Recently, methods for the extraction of proteins from formalin-fixed, paraffin-embedded (FFPE) tissues have become available. In this ...Continue Reading

References

Apr 29, 1998·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K IkedaM Monden
Jan 23, 1999·Nature Genetics·L ShayestehJ W Gray
Nov 6, 2001·Oncology·M PiccartD Larsimont
Feb 2, 2002·Nature·Laura J van 't VeerStephen H Friend
Mar 5, 2002·Nature Biotechnology·Peter Mitchell
Mar 22, 2002·Trends in Biotechnology·Markus F TemplinThomas O Joos
Nov 28, 2002·Nature Genetics·Emanuel F PetricoinFrank D Sistare
May 3, 2003·Cancer Cell·Lance A LiottaEmanuel F Petricoin
May 24, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P A BaakE A M Janssen
Dec 9, 1961·Nature·J G FEINBERG
Nov 5, 2003·Proteomics·Virginia EspinaLance A Liotta
Nov 5, 2003·Proteomics·Robert L GrubbEmanuel F Petricoin
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Satoshi NishizukaJohn N Weinstein
Jul 21, 2004·Journal of Immunological Methods·Virginia EspinaLance A Liotta
Nov 16, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Julia WulfkuhleEmanuel Petricoin
May 3, 2005·The Lancet Oncology·Jing Yuan Fang, Bruce C Richardson
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
May 3, 2005·Journal of Cancer Research and Clinical Oncology·Wolfgang J KöstlerChristoph C Zielinski
Aug 11, 2005·Molecular & Cellular Proteomics : MCP·Brian L HoodDavid B Krizman
Aug 30, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Wei-Sing ChuMaokai Gong
Sep 13, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·David K CrockettKojo S J Elenitoba-Johnson
Dec 13, 2005·Journal of Proteome Research·Darryl Erik Palmer-ToySaumil N Merchant
Dec 31, 2005·Journal of Proteome Research·Linda Sage
Jan 10, 2006·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Shan-Rong ShiClive R Taylor
May 10, 2006·Nature Clinical Practice. Oncology·Julia D WulfkuhleEmanuel F Petricoin
Jun 1, 2006·Virchows Archiv : an International Journal of Pathology·Manfred Dietel, Christine Sers
Jun 22, 2006·Current Medicinal Chemistry·K-F BeckerH Höfler
May 29, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Carol B FowlerJeffrey T Mason
Jun 5, 2007·The International Journal of Biochemistry & Cell Biology·Christian WidakowichMartine Piccart-Gebhart
Jan 1, 2008·The Oncologist·Christian WidakowichAhmad Awada
Feb 9, 2008·Journal of Proteome Research·Julia D WulfkuhleEmanuel F Petricoin
Jun 20, 2008·Molecular BioSystems·Niroshini J NirmalanRosamonde E Banks
Apr 28, 2009·The Journal of Pathology·Christian GulmannEmanuel F Petricoin
Nov 3, 2009·Biochemical Pharmacology·Bo HongAnthony T C Chan
Nov 17, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Daniela BergKarl-Friedrich Becker
Mar 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chandra BartholomeuszNaoto T Ueno
Mar 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrew G SikoraWillem W Overwijk

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Citations

May 9, 2013·Molecular & Cellular Proteomics : MCP·Maziar AssadiThomas Schindler
Apr 19, 2012·Science Signaling·Boris KholodenkoWalter Kolch
Jul 6, 2014·Clinical Proteomics·Emily S Boja, Henry Rodriguez
Nov 20, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Anton B Iliuk, W Andy Tao
Jul 28, 2015·Expert Review of Molecular Diagnostics·Stefanie Boellner, Karl-Friedrich Becker
Aug 29, 2013·Biopharmaceutics & Drug Disposition·Ioannis N MelasLeonidas G Alexopoulos
Feb 13, 2014·Proteomics·Corinne Solier, Hanno Langen
Jul 15, 2016·Virchows Archiv : an International Journal of Pathology·Giorgio StantaGerald Hoefler
Aug 30, 2013·Journal of Proteome Research·Sibylle GündischKarl-Friedrich Becker
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rodrigo DienstmannJosep Tabernero
Oct 13, 2016·Oncotarget·Carolin GötzAndreas Kolk
Jul 16, 2010·Molecular Human Reproduction·Caroline E Gargett, Hirotaka Masuda

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