Deciphering the cause of evolutionary variance within intrinsically disordered regions in human proteins

Journal of Biomolecular Structure & Dynamics
Sanghita BanerjeeRajat K De

Abstract

Why the intrinsically disordered regions evolve within human proteome has became an interesting question for a decade. Till date, it remains an unsolved yet an intriguing issue to investigate why some of the disordered regions evolve rapidly while the rest are highly conserved across mammalian species. Identifying the key biological factors, responsible for the variation in the conservation rate of different disordered regions within the human proteome, may revisit the above issue. We emphasized that among the other biological features (multifunctionality, gene essentiality, protein connectivity, number of unique domains, gene expression level and expression breadth) considered in our study, the number of unique protein domains acts as a strong determinant that negatively influences the conservation of disordered regions. In this context, we justified that proteins having a fewer types of domains preferably need to conserve their disordered regions to enhance their structural flexibility which in turn will facilitate their molecular interactions. In contrast, the selection pressure acting on the stretches of disordered regions is not so strong in the case of multi-domains proteins. Therefore, we reasoned that the presence of co...Continue Reading

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Citations

Jul 2, 2016·Journal of Biomolecular Structure & Dynamics·Alessandra ApicellaChristopher J G Plummer
Apr 11, 2017·Journal of Biomolecular Structure & Dynamics·Meng GaoYongqi Huang

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Datasets Mentioned

BETA
GSE1133

Software Mentioned

SPSS
in
EMBOSS Transeq
house Perl script
PONDR
R
SignaLink
MAFFT
ESpritz tools
BLAST

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