Deciphering the microRNA transcriptome of skeletal muscle during porcine development

PeerJ
Miaomiao MaiXuewei Li

Abstract

MicroRNAs (miRNAs) play critical roles in many important biological processes, such as growth and development in mammals. Various studies of porcine muscle development have mainly focused on identifying miRNAs that are important for fetal and adult muscle development; however, little is known about the role of miRNAs in middle-aged muscle development. Here, we present a comprehensive investigation of miRNA transcriptomes across five porcine muscle development stages, including one prenatal and four postnatal stages. We identified 404 known porcine miRNAs, 118 novel miRNAs, and 101 miRNAs that are conserved in other mammals. A set of universally abundant miRNAs was found across the distinct muscle development stages. This set of miRNAs may play important housekeeping roles that are involved in myogenesis. A short time-series expression miner analysis indicated significant variations in miRNA expression across distinct muscle development stages. We also found enhanced differentiation- and morphogenesis-related miRNA levels in the embryonic stage; conversely, apoptosis-related miRNA levels increased relatively later in muscle development. These results provide integral insight into miRNA function throughout pig muscle development ...Continue Reading

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Citations

Jul 19, 2020·Animals : an Open Access Journal From MDPI·Guofang WuChen Yang
Aug 21, 2020·Asian-Australasian Journal of Animal Sciences·Ambreen IqbalZhao Zhihui
Mar 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiao ChengLi Zhu

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Methods Mentioned

BETA
PCR

Software Mentioned

PicTar
Mfold
Image Pro - Plus
SPSS
DAVID
MultiExperiment Viewer ( MeV )
TargetScan Human
STEM

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