Deciphering the neural underpinnings of alexithymia in multiple sclerosis.

Neuroscience Letters
Moussa A ChalahSamar S Ayache

Abstract

Alexithymia is a personality construct that could occur in up to 53 % of patients with multiple sclerosis (MS). It entails difficulties in identifying and describing one's feelings and an externally oriented thinking. The current work aims to assess the neural underpinnings of alexithymia in this population. Forty-five patients with MS filled in the Toronto Alexithymia Scale (n = 17 with high alexithymia and n = 28 with low alexithymia). Brain magnetic resonance imaging was obtained for each patient and a morphometry algorithm (MorphoBox) was applied to calculate regional brain volumes. All patients underwent a clinical and neuropsychological evaluation which included measures for anxiety, depression, fatigue, daytime sleepiness, and basic and social cognition. Compared to patients with low alexithymia, patients with high alexithymia had significantly higher fatigue and depression ratings, and lower empathy scores. In addition, they had lower volumes of corpus callosum, deep white matter, pallidum bilaterally, and left thalamus. In the whole cohort, alexithymia scores were inversely correlated with gray matter (thalamus and pallidum bilaterally) and white matter volumes (corpus callosum and bilateral deep white matter) after co...Continue Reading

References

Jan 1, 1977·Psychotherapy and Psychosomatics·K D Hoppe, J E Bogen
Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Sep 1, 1991·Comprehensive Psychiatry·J D ParkerG J Taylor
Nov 1, 1989·The American Journal of Psychiatry·S B ZeitlinM J Schrift
Jan 1, 1985·Psychotherapy and Psychosomatics·G Fricchione, E Howanitz
Jan 1, 1973·Psychotherapy and Psychosomatics·P E Sifneos
Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Aug 12, 1999·Psychosomatic Medicine·J D ParkerG J Taylor
Jun 12, 2001·Journal of Psychosomatic Research·G LoasUNKNOWN Réseau INSERM no. 494013
Jun 5, 2003·Journal of Psychosomatic Research·Junilla K LarsenRon Hijman
Sep 7, 2006·International Journal of Geriatric Psychiatry·Mani S KrishnanUNKNOWN LADIS Group
Mar 14, 2007·Cognitive Neuropsychiatry·Bob BermondPeter P Moormann
May 1, 2008·Neuropsychology·Lavanya VijayaraghavanSergio Paradiso
Aug 5, 2008·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sylvie BerthozJulie Grèzes
Oct 31, 2008·Lancet·Alastair Compston, Alasdair Coles
Jun 12, 2010·The Kaohsiung Journal of Medical Sciences·Mei-Feng HuangCheng-Sheng Chen
Sep 3, 2011·Biological Psychology·Simone LangSven Barnow
Jan 11, 2013·BioPsychoSocial Medicine·Michiko Kano, Shin Fukudo
Aug 13, 2013·Psychiatry Research·Erwin LemcheVincent P Giampietro
Apr 5, 2014·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Jorien van der VeldeAndré Aleman
Nov 28, 2014·NeuroImage. Clinical·Daniel SchmitterUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Jun 23, 2015·Human Brain Mapping·Katharina Sophia Goerlich-DobreClaus Lamm
Jun 23, 2015·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·E GleichgerrchtV Sinay
Dec 10, 2015·Frontiers in Cellular Neuroscience·Moussa A ChalahSamar S Ayache
Jan 11, 2017·Journal of the International Neuropsychological Society : JINS·Moussa A Chalah, Samar S Ayache
Mar 30, 2017·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Moussa A Chalah, Samar S Ayache
Aug 3, 2017·Neuropsychologia·Moussa A Chalah, Samar S Ayache
Nov 21, 2017·Journal of Experimental Psychology. General·Jennifer MurphyGeoffrey Bird
Dec 26, 2017·Lancet Neurology·Alan J ThompsonJeffrey A Cohen
Jan 24, 2018·Neuroscience and Biobehavioral Reviews·Pengfei XuAndré Aleman
Jul 11, 2018·Dementia & Neuropsychologia·Audred Cristina Biondo EboniYara Dadalti Fragoso
Nov 2, 2018·Psychiatry Research·Christian BanzhafFelix Bermpohl
Dec 31, 2018·Multiple Sclerosis and Related Disorders·Moussa A ChalahSamar S Ayache
Dec 28, 2019·Brain Sciences·Samar S Ayache, Moussa A Chalah

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Citations

Feb 3, 2021·The International Journal of Neuroscience·Triantafyllos DoskasΚonstantinos Vadikolias

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