Deciphering the oligodendrogenic program of neural progenitors: cell intrinsic and extrinsic regulators

Stem Cells and Development
Francisco J RiveraLudwig Aigner

Abstract

In the developing and adult CNS, neural stem/progenitor cells (NSPCs) and oligodendroglial progenitor cells (OPCs) follow an oligodendrogenic process with the aim of myelinating axons. This process is to a high degree regulated by an oligodendrogenic program (OPr) composed of intrinsic and extrinsic factors that modulate the different steps required for NSPCs to differentiate into myelinating oligodendrocytes. Even though NSPCs and OPCs are present in the diseased CNS and have the capacity to generate oligodendrocytes, sparse remyelination of axons constitutes a major constraint in therapies toward multiple sclerosis (MS) and spinal cord injury (SCI). Lack of pro-oligodendrogenic factors and presence of anti-oligodendrogenic activities are thought to be the main reasons for this limitation. Thus, molecular and cellular strategies aiming at remyelination and at targeting such pro- and anti-oligodendrogenic mechanisms are currently under investigation. The present review summarizes the current knowledge on the OPr; it implements our own findings on mesenchymal stem cell-derived pro-oligodendroglial factors and on the role of p57/kip2 in oligodendroglial differentiation. Moreover, it describes molecular and cellular approaches for...Continue Reading

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Citations

Feb 11, 2012·Cell and Tissue Research·Janusz J JadaszPatrick Küry
Nov 15, 2011·Stem Cells and Development·Carolin SteffenhagenFrancisco J Rivera
Jul 8, 2015·International Journal of Molecular Sciences·Peter Göttle, Patrick Küry
Feb 3, 2016·Frontiers in Cellular Neuroscience·Francisco J RiveraLudwig Aigner
Aug 29, 2012·Molecular and Cellular Neurosciences·H B Stolp
Mar 12, 2016·Trends in Neurosciences·David KremerPatrick Küry
Nov 18, 2016·International Journal of Molecular Sciences·Rainer AkkermannPatrick Küry
Dec 15, 2016·Frontiers in Cellular Neuroscience·Tânia Lourenço, Mário Grãos
Apr 12, 2019·Frontiers in Cellular Neuroscience·Maria Elena SilvaFrancisco J Rivera
May 30, 2017·Neural Regeneration Research·Rainer AkkermannPatrick Küry
Sep 20, 2017·Developmental Neurobiology·Bethany R Kondiles, Philip J Horner
Jun 21, 2018·Scientific Reports·Chan-Il ChoiIsobel A Scarisbrick
Aug 6, 2011·Molecular Cancer Research : MCR·Adriana BorrielloFulvio Della Ragione
Aug 10, 2012·Development·Janusz J JadaszPatrick Küry

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Methods Mentioned

BETA
nuclear translocation

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