Decision-making for and impact of early immunomodulatory treatment: the Austrian Clinically Isolated Syndrome Study (ACISS)

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
F FazekasK Vass

Abstract

When to start disease-modifying treatment (DMT) in patients with a clinically isolated syndrome (CIS) requires individual weighing of benefits versus possible burden of side effects and costs. How this occurs in a routine setting is barely known. The aim of the study was to investigate the decision-making process regarding immediate or later DMT and the ensuing impact on CIS patients in Austria. Demographic and (para) clinical characteristics of 296 CIS patients were recorded in 29 multiple sclerosis (MS) centres, and the patients' overall condition was rated on a visual analogue scale (VAS). Clinical follow-up and VAS ratings were repeated at 6-month intervals over 2 years. The decision for initiation of DMT was at the physician's and patient's discretion. In 29% of patients, DMT was started within 3 months and this decision was independently associated with a T2-lesion number >or=9 on MRI and a worse VAS rating by the physician. DMT initiation in the subsequent 6 months was additionally associated with the presence of oligoclonal bands and rarely occurred thereafter. Adapted to the clinical course, later treatment was associated with the highest rate of conversion to clinically definite MS and greatest disability after 2 year...Continue Reading

References

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Citations

Dec 29, 2016·The International Journal of Neuroscience·Maurice DahdalehMagd Zakaria
Apr 26, 2017·The Cochrane Database of Systematic Reviews·Graziella FilippiniGeorgia Salanti
May 16, 2014·International Journal of Food Sciences and Nutrition·Jagan Mohan Rao TingirikariArun Goyal

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