Decision-making impairments under ambiguous and risky situations in patients with prefrontal tumor: A neuropsychological study.

Brain and Behavior
Yuyang WangXingui Chen

Abstract

The neural mechanism underlying decision-making, which is an important component of executive function, is complex and not fully understood. Few studies have directly investigated the two types of decision-making functions - under ambiguity and under risk - in patients with brain tumors in different brain regions. Participants were classified into the ventral prefrontal cortex tumor group (VPFC, n = 27), the dorsolateral prefrontal cortex tumor group (DLPFC, n = 29), and matched healthy controls (HCs, n = 32). All participants were given a battery of neuropsychological tests, and they then performed the Iowa Gambling Task (IGT) and the Game of Dice Task (GDT) to assess their decision-making under ambiguity and under risk, respectively. The two patient groups performed significantly worse on attention, memory, information processing, and executive function. Additionally, patients in the DLPFC group performed significantly worse on the memory and information processing tests compared with the VPFC and HC groups. This study found that the decision-making functions of participants in the VPFC and DLPFC tumor groups were impaired to varying degrees. Among them, there was decision-making impairment under ambiguity and under risk in t...Continue Reading

References

Dec 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·E T RollsJ McGrath
Jun 1, 1996·Neuropsychologia·S C BakerT W Robbins
Feb 28, 1997·Science·A BecharaA R Damasio
Sep 25, 2001·Behavioural Neurology·Chris Rorden, Matthew Brett
Mar 2, 2002·Brain : a Journal of Neurology·Facundo ManesTrevor Robbins
Apr 3, 2002·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Monique ErnstEdythe D London
May 2, 2003·Annals of the New York Academy of Sciences·Antoine BecharaAntonio R Damasio
Feb 12, 2005·Behavioural Neurology·Matthias BrandHans J Markowitsch
Aug 13, 2005·Biological Psychiatry·Monique Ernst, Martin P Paulus
Oct 20, 2006·Brain and Cognition·Paula Adriana Rodrigues GouveiaOrlando Francisco Amodeo Bueno
Aug 21, 2007·Psychiatry Research·Kirsten LabuddaMatthias Brand
Oct 27, 2007·Science·Etienne Koechlin, Alexandre Hyafil
Jan 15, 2008·Cognitive, Affective & Behavioral Neuroscience·Mattew M Botvinick
Jan 31, 2008·Cognitive Processing·Matthias BrandHans J Markowitsch
Mar 28, 2008·Nature Neuroscience·Michael L Platt, Scott A Huettel
May 20, 2008·Drug and Alcohol Dependence·Matthias BrandHans J Markowitsch
Sep 13, 2008·Cerebral Cortex·Natalia S LawrenceMary L Phillips
Sep 25, 2009·Human Brain Mapping·Xiangrui LiAntoine Bechara
Jul 1, 2000·Cognitive Neuropsychology·V Goel, J Grafman
Jan 28, 2012·Cognitive, Affective & Behavioral Neuroscience·Tara A NiendamCameron S Carter
Oct 9, 2012·Journal of Psychiatric Research·Pedro G AlvarengaMarcelo Q Hoexter
May 29, 2013·Cognitive, Affective & Behavioral Neuroscience·Stefan KaiserAndreas Mojzisch

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