Decision-making under uncertainty in obsessive-compulsive disorder

Journal of Psychiatric Research
Helen PushkarskayaIfat Levy

Abstract

Obsessive compulsive disorder (OCD) produces profound morbidity. Difficulties with decision-making and intolerance of uncertainty are prominent clinical features in many patients. The nature and etiology of these deficits are poorly understood. We used a well-validated choice task, grounded in behavioral economic theory, to investigate differences in valuation and value-based choice during decision making under uncertainty in 20 unmedicated participants with OCD and 20 matched healthy controls. Participants' choices were used to assess individual decision-making characteristics. OCD participants did not differ from healthy controls in how they valued uncertain options when outcome probabilities were known (risk) but were more likely than healthy controls to avoid uncertain options when these probabilities were imprecisely specified (ambiguity). Compared to healthy controls, individuals with OCD were less consistent in their choices and less able to identify options that should be clearly preferable. These abnormalities correlated with symptom severity. These results suggest that value-based choices during decision-making are abnormal in OCD. Individuals with OCD show elevated intolerance of uncertainty, but only when outcome pr...Continue Reading

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Citations

Sep 14, 2016·Schizophrenia Research·Junya FujinoHidehiko Takahashi
Aug 22, 2017·Molecular Autism·Junya FujinoHidehiko Takahashi
Feb 7, 2019·Brain : a Journal of Neurology·Alekhya MandaliValerie Voon
Jun 1, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Ifat Levy
Sep 29, 2019·European Archives of Psychiatry and Clinical Neuroscience·Junya FujinoHidehiko Takahashi
May 19, 2017·Scientific Reports·Joshua W BuckholtzArielle Baskin-Sommers
Dec 20, 2019·Human Brain Mapping·Junya FujinoMotoaki Nakamura
Jan 31, 2018·Frontiers in Psychiatry·Kamila E SipEmily R Stern
Nov 12, 2020·Neuropsychology Review·Jessica E Tschida, Benjamin E Yerys
Jan 2, 2021·Trends in Cognitive Sciences·Ifat Levy, Daniela Schiller
Dec 11, 2019·Neuroscience and Biobehavioral Reviews·Aleya A MarzukiTrevor W Robbins
Feb 23, 2020·Drug and Alcohol Dependence·Ranjita PoudelMatthew T Sutherland
Jul 15, 2021·European Archives of Psychiatry and Clinical Neuroscience·Vera FlasbeckParaskevi Mavrogiorgou
Sep 23, 2021·Journal of Behavioral Addictions·Małgorzata DrapsMateusz Gola
Dec 9, 2020·Current Biology : CB·Ilya E MonosovAhmad Jezzini

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