Decision Support for Medication Change of Parkinson's Disease Patients

Computer Methods and Programs in Biomedicine
Biljana Mileva BoshkoskaM Bohanec

Abstract

Parkinson's disease (PD) is a degenerative disorder of the central nervous system for which currently there is no cure. Its treatment requires long-term, interdisciplinary disease management, and usage of typical medications, including levodopa, dopamine agonists, and enzymes, such as MAO-B inhibitors. The key goal of disease management is to prolong patients' independence and keep their quality of life. Due to the different combinations of motor and non-motor symptoms from which PD patients suffer, in addition to existing comorbidities, the change of medications and their combinations is difficult and patient-specific. To help physicians, we developed two decision support models for PD management, which suggest how to change the medication treatment. The models were developed using DEX methodology, which integrates the qualitative multi-criteria decision modelling with rule-based expert systems. The two DEX models differ in the way the decision rules were defined. In the first model, the decision rules are based on the interviews with neurologists (DEX expert model), and in the second model, they are formed from a database of past medication change decisions (DEX data model). We assessed both models on the Parkinson's Progress...Continue Reading

References

Sep 9, 2000·International Journal of Medical Informatics·M BohanecV Rajkovic
Nov 6, 2002·Journal of Biomedical Informatics·Vimla L PatelJose F Arocha
Jan 8, 2003·PharmacoEconomics·Michael Iskedjian, Thomas R Einarson
Sep 16, 2004·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Uwe SiebertRichard C Dodel
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Nov 26, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Christopher G GoetzUNKNOWN Movement Disorder Society UPDRS Revision Task Force
Nov 26, 2009·The Journal of International Medical Research·O SustersicVladislav Rajkovic
Sep 21, 2011·Progress in Neurobiology·UNKNOWN Parkinson Progression Marker Initiative
Nov 2, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Susan H FoxCristina Sampaio
Nov 2, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Klaus SeppiCristina Sampaio
Dec 3, 2011·Movement Disorders : Official Journal of the Movement Disorder Society·Daniel WeintraubAndrew Siderowf
Sep 25, 2012·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Uwe SiebertUNKNOWN ISPOR-SMDM Modeling Good Research Practices Task Force
Jul 15, 2017·Healthcare Technology Letters·Kostas M TsiourisDimitrios I Fotiadis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.