Decline in Pneumococcal Disease Attenuated in Older Adults and Those With Comorbidities Following Universal Childhood PCV13 Immunization

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Stephen I PeltonDerek Weycker

Abstract

Following introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in the United States, epidemiology of pneumococcal disease shifted such that disease incidence in the elderly exceeded that in children. We evaluated the impact of replacing PCV7 with PCV13 on disease burden in adults and identified age/risk-specific subgroups with the highest remaining disease burden. A retrospective design and data from two US healthcare claims repositories were used. Study population included adults aged ≥18 years and was stratified by age (18-49, 50-64, 65-74, ≥75) and risk profile (healthy, at-risk, high-risk). Rate ratios comparing invasive pneumococcal disease (IPD), all-cause hospitalized pneumonia (ACHP), and pneumococcal pneumonia requiring hospitalization among at-risk and high-risk adults vs healthy counterparts were estimated for 2007-2010 (pre-PCV13), 2011-2012 (peri-PCV13), and 2013-2015 (post-PCV13). Across study periods, IPD and ACHP rates increased with age (2-27 times higher in persons ≥75 vs 18-49) and comorbidity (4-20 times higher in high-risk vs healthy). From pre- to post-PCV13 period, IPD rates declined 5%-48% and ACHP rates declined 4%-19% across age and risk groups (ACHP did not decline in persons ≥75). Decline i...Continue Reading

References

Jul 5, 2005·The Journal of Infectious Diseases·Moe H KyawUNKNOWN Active Bacterial Core Surveillance Program of the Emerging Infections Program Network
Oct 27, 2005·JAMA : the Journal of the American Medical Association·Catherine A LexauUNKNOWN Active Bacterial Core Surveillance Team
Dec 2, 2009·The Journal of Infectious Diseases·Tamara PilishviliUNKNOWN Active Bacterial Core Surveillance/Emerging Infections Program Network
Mar 8, 2012·The Journal of Infection·Albert Jan van HoekElizabeth Miller
Apr 5, 2012·JAMA : the Journal of the American Medical Association·Peter K LindenauerMichael B Rothberg
Nov 17, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Riyadh D MuhammadMatthew R Moore
May 16, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Stephen I PeltonJohn Edelsberg
Mar 4, 2015·Open Forum Infectious Diseases·Kimberly M SheaStephen I Pelton

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Citations

Feb 14, 2019·Expert Review of Vaccines·Andrew D WieseCarlos G Grijalva
Sep 17, 2020·JAMA Surgery·Fabio CascianiCharles M Vollmer
May 16, 2020·F1000Research·Charles Feldman, Ronald Anderson
Oct 3, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kimiko UbukataSatoshi Iwata
Jun 5, 2021·Respiratory Medicine·Ahuva AverinStephen I Pelton

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