PMID: 6408644Jul 1, 1983Paper

Decline of follicular oocyte maturation inhibitor coincident with maturation and achievement of fertilizability of oocytes recovered at midcycle of gonadotropin-treated women

Proceedings of the National Academy of Sciences of the United States of America
C P ChanningH Jones

Abstract

To examine whether a decline in follicular oocyte maturation inhibitor (OMI) is associated with attainment of oocyte maturation and fertilizability, OMI was measured in follicular fluid (FF) of 39 follicles of 20 normal women given human menopausal gonadotrophin and human chorionic gonadotrophin to induce follicular growth and maturation. Oocytes were aspirated per laparoscope, the fluid was saved, and the egg was observed, incubated, and inseminated with the husband's sperm. Concepti that developed to the 4- to 8-cell stage were transferred to the uterus and the women were followed for pregnancy. OMI activity in each FF was measured by using cultured cumulus-enclosed porcine oocytes (30-40 oocytes per FF sample). Estrogen, progesterone, oocytes (30-40 oocytes per FF sample). Estrogen, progesterone, and delta 4-androstenedione were measured in FF by radioimmunoassay. The FF of 13 preovulatory follicles yielding oocytes that were mature and fertilizable had significantly less OMI activity (mean +/- SEM) (0.58 +/- 0.10 unit/ml) compared to follicles yielding immature oocytes (2.8 +/- 0.56 units/ml; n = 9), atretic oocytes (5.5 +/- 2.5 units/ml; n = 7), or preovulatory oocytes with fractured zonae (1.9 +/- 0.63 units/ml; n = 7). T...Continue Reading

References

Apr 1, 1977·Metabolism: Clinical and Experimental·C P Channing, A Tsafriri
Jul 1, 1978·The Journal of Endocrinology·Z KraiemB Lunefeld
Dec 1, 1978·The Journal of Clinical Endocrinology and Metabolism·T HillensjöC P Channing
Apr 1, 1979·Molecular and Cellular Endocrinology·F Ledwitz-Rigby, B W Rigby
Apr 1, 1975·Journal of Reproduction and Fertility·A Tsafriri, C P Channing
Dec 1, 1966·Journal of Reproduction and Fertility·R H Hunter, C Polge
Jun 1, 1981·The Journal of Clinical Endocrinology and Metabolism·C P ChanningP Lebech
Mar 1, 1982·Journal of Reproduction and Fertility·A O TrounsonJ F Leeton

❮ Previous
Next ❯

Citations

Dec 1, 1984·Journal of in Vitro Fertilization and Embryo Transfer : IVF·S L WeimerG S Dizerega
Feb 1, 1988·Journal of in Vitro Fertilization and Embryo Transfer : IVF·D Navot, Z Rosenwaks
Aug 1, 1987·Journal of in Vitro Fertilization and Embryo Transfer : IVF·A PellicerF Naftolin
May 6, 2009·Reproductive Biology and Endocrinology : RB&E·Alberto RevelliPaolo Rinaudo
Jan 1, 1985·Annals of the New York Academy of Sciences·T HillensjöJ Törnell
Feb 1, 1986·Clinics in Endocrinology and Metabolism·S A Tonetta, G S diZerega
Feb 1, 1986·Clinics in Endocrinology and Metabolism·A Tsafriri, S H Pomerantz
Jan 1, 1985·Annals of the New York Academy of Sciences·L L Veeck
Feb 24, 2000·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·S J Fasouliotis, J G Schenker
Jun 1, 2005·Human Reproduction Update·Jean CohenLars Hamberger

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.