Decline of HPV infections in Scandinavian cervical screening populations after introduction of HPV vaccination programs.

Vaccine
Joakim DillnerSusanne K Kjaer

Abstract

To monitor the changes in prevalence of human papillomavirus (HPV) infections in women <50 years of age, participating in cervical screening programs of Denmark, Norway, and Sweden, before and after introduction of quadrivalent HPV (qHPV) vaccination. Liquid-based cytology samples were collected from 6538 women who attended cervical screening in Denmark, Norway, and Sweden in 2006-2008 and from 6332 similarly enrolled women in 2012-2013. Denmark started organized qHPV vaccination in 2008, Norway in 2009, and Sweden in 2012. All HPV testing and genotyping was performed using identical enrollment and analysis methods, by accredited general primer polymerase chain reaction methods with typing using the Luminex system. Overall HPV positivity declined slightly from 36.5% in 2006-2008 to 34.5% in 2012-2013. The decline was most pronounced among women 18-26 years of age: from 54.4% to 48.1% (P < 0.001). The decline was substantial for vaccine HPV types (HPV6/11/16/18: decline from 22.3% to 16.6%; P < 0.001) and was seen for both low-risk vaccine types (HPV6/11 declined from 5.0% to 2.5%) and high-risk vaccine types (HPV16/18 declined from 18.9% to 14.9%). Among women 27-50 years of age, there was no change between the time periods (22...Continue Reading

Citations

Dec 28, 2019·BJOG : an International Journal of Obstetrics and Gynaecology·M SkorstengaardG Napolitano
Jan 24, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Giorgio BoganiFrancesco Raspagliesi
Sep 30, 2020·Human Vaccines & Immunotherapeutics·Mari NygårdJoakim Dillner
Dec 24, 2019·International Journal of Cancer. Journal International Du Cancer·Hanna KannHelena Faust
Aug 3, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Giorgio BoganiFrancesco Raspagliesi
Jul 14, 2020·Vaccine·Peter Sasieni, Alejandra Castanon
Sep 24, 2021·Scientific Reports·Laila Sara Arroyo MührEmilie Hultin
Oct 12, 2021·Frontiers in Cellular and Infection Microbiology·Javier Freire-SalinasJavier Gómez-Román

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