Decline of substance P levels after stress management with cognitive behaviour therapy in women with the fibromyalgia syndrome.

Scandinavian Journal of Pain
Bo KarlssonKurt Svärdsudd

Abstract

Background and aims Substance P (CSF-SP) is known to be elevated in females with fibromyalgia syndrome (FMS). The aims of this study were to evaluate the effect of cognitive behaviour therapy (CBT) on plasma SP levels in women with FMS and to find possible clinical behavioural correlates to plasma SP level changes. Methods Forty-eight women with FMS were randomly allocated into two groups. Group 1 received the CBT treatment intervention over the course of 6 months while group 2 was waitlisted. CBT was given with a protocol developed to diminish stress and pain. After 6 months, group 2 was given the same CBT treatment as well. All were followed up 1 year after the start of CBT treatment. This approach allowed for two analytical designs - a randomised controlled trial (RCT) (n=24 vs. n=24) and a before-and-after treatment design (n=48). All women were repeatedly evaluated by the West Haven-Yale Multidimensional Pain Inventory (MPI) and three other psychometric questionnaires and plasma SP was analysed. Results In the RCT design, the plasma SP level was 8.79 fmol/mL in both groups at the start of the trial, after adjustment for initial differences. At the end of the RCT, the plasma SP level was 5.25 fmol/mL in the CBT intervention...Continue Reading

References

Apr 1, 1979·The British Journal of Psychiatry : the Journal of Mental Science·S A Montgomery, M Asberg
Oct 1, 1987·International Journal of Cardiology·A AppelsP Mulder
Dec 1, 1985·Pain·Robert D KernsThomas E Rudy
Dec 1, 1993·Journal of Psychosomatic Research·A AppelsE G Schouten
Jun 29, 2000·Trends in Pharmacological Sciences·R Hill
Oct 4, 2002·International Journal of Behavioral Medicine·Gunilla Burell, Brittmarie Granlund
Apr 23, 2003·Perceptual and Motor Skills·Birgitta Hellström, Ulla Maria Anderberg
Oct 14, 2003·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Maria ClaessonKjell Asplund
Aug 5, 2004·Psychotherapy and Psychosomatics·Boudewijn Van Houdenhove, Ulrich T Egle
Oct 17, 2006·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Tiffany FieldSteven Douglas
Jul 2, 2009·Psychiatry and Clinical Neurosciences·Ling LiYumin Luo
Jan 9, 2010·The American Journal of Medicine·Daniel J Clauw
Jul 16, 2010·The Journal of Pain : Official Journal of the American Pain Society·Katja WingenfeldStefan Lautenbacher
Jun 23, 2011·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Pamela LyonJohn Quintner
Jul 1, 2011·International Journal of Behavioral Medicine·Sungkun ChoJames McKoy
Oct 24, 2012·European Journal of Pain : EJP·R K WicksellG L Olsson
Jun 8, 2013·Maturitas·Jacob N Ablin, Dan Buskila
Jun 19, 2018·Scandinavian Journal of Pain·Bo KarlssonKurt Svärdsudd
Oct 5, 2018·Cell and Tissue Research·W Zieglgänsberger

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