Declines in Pneumonia and Meningitis Hospitalizations in Children Under 5 Years of Age After Introduction of 10-Valent Pneumococcal Conjugate Vaccine in Zambia, 2010-2016

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Evans M MpabalwaniFernanda C Lessa

Abstract

Pneumococcus is a leading cause of pneumonia and meningitis. Zambia introduced a 10-valent pneumococcal conjugate vaccine (PCV10) in July 2013 using a 3-dose primary series at ages 6, 10, and 14 weeks with no booster. We evaluated the impact of PCV10 on meningitis and pneumonia hospitalizations. Using hospitalization data from first-level care hospitals, available at the Ministry of Health, and from the largest pediatric referral hospital in Lusaka, we identified children aged <5 years who were hospitalized with pneumonia or meningitis from January 2010-December 2016. We used time-series analyses to measure the effect of PCV10 on monthly case counts by outcome and age group (<1 year, 1-4 years), accounting for seasonality. We defined the pre- and post-PCV10 periods as January 2010-June 2013 and July 2014-December 2016, respectively. At first-level care hospitals, pneumonia and meningitis hospitalizations among children aged <5 years accounted for 108 884 and 1742 admissions in the 42 months pre-PCV10, respectively, and 44 715 and 646 admissions in the 30 months post-PCV10, respectively. Pneumonia hospitalizations declined by 37.8% (95% confidence interval [CI] 21.4-50.3%) and 28.8% (95% CI 17.7-38.7%) among children aged <1 yea...Continue Reading

References

Oct 3, 2003·The New England Journal of Medicine·Keith P KlugmanVaccine Trialists Group
Aug 26, 2006·Tropical Medicine & International Health : TM & IH·A RocaPedro L Alonso
Nov 28, 2012·The Journal of Infectious Diseases·Andros TheoMwaka Monze
Apr 16, 2013·Lancet·Christa L Fischer WalkerRobert Black
Jul 12, 2013·The New England Journal of Medicine·Marie R GriffinCarlos G Grijalva
Jun 4, 2018·Travel Medicine and Infectious Disease·Mariëlle van AalstGodelieve J de Bree
Jun 12, 2018·PloS One·Anouk M Oordt-SpeetsMoe H Kyaw

Methods Mentioned

BETA
X-ray

Related Concepts

10-valent pneumococcal conjugate vaccine
Child, Preschool
Hospitalization
Hospitals, Pediatric
Homo sapiens
Infant
Transcription, Medical
Streptococcal Pneumonia
Zambia
Meningitis, Bacterial

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