Declining beta-cell compensation for insulin resistance in Hispanic women with recent gestational diabetes mellitus: association with changes in weight, adiponectin, and C-reactive protein.

Diabetes Care
A XiangT A Buchanan

Abstract

To identify factors associated with declining beta-cell compensation for insulin resistance. In a cohort of Hispanic women with recent gestational diabetes mellitus, oral glucose tolerance tests (OGTTs), intravenous glucose tolerance tests (IVGTTs), and bioelectrical impedance measurements were performed at 15-month intervals for up to 5 years, or until fasting plasma glucose exceeded 140 mg/dl (7.8 mmol/l). Data were analyzed to identify predictors of declining beta-cell compensation for insulin resistance (the disposition index [DI]) and to examine the mechanism of weight gain and changes in circulating levels of selected adipokines and inflammatory markers on beta-cell compensation decline. A total of 60 nondiabetic women had a median of four sets of OGTT + IVGTT during a median follow-up of 52 months. Fourteen of the women developed diabetes. None of the baseline characteristics were significantly predictive of a decline in DI. There were significant univariate associations between declining DI and weight gain (specifically fat gain), declining adiponectin and rising C-reactive protein. Multivariate analysis showed that the weight gain was the most significant factor associated with declining DI. The amount of association b...Continue Reading

References

Jul 24, 2001·JAMA : the Journal of the American Medical Association·A D PradhanP M Ridker
Feb 8, 2002·The New England Journal of Medicine·William C KnowlerUNKNOWN Diabetes Prevention Program Research Group
May 22, 2002·The Journal of Clinical Investigation·Ripudaman S HundalGerald I Shulman
Jul 13, 2002·Lancet·Robert S LindsayJonathan Krakoff
Dec 28, 2002·Diabetes Care·UNKNOWN Expert Committee on the Diagnosis and Classification of Diabetes Mellitus
Jan 28, 2003·Lancet·Joachim SprangerAndreas F H Pfeiffer
Apr 13, 2007·The New England Journal of Medicine·Claus M LarsenMarc Y Donath
Oct 26, 2007·Diabetes Care·Amy FleischmanAllison B Goldfine
Dec 1, 2007·Endocrine Reviews·Marc Y DonathThomas Mandrup-Poulsen
Dec 1, 2007·Endocrine Reviews·Vincent Poitout, R Paul Robertson
Apr 26, 2008·Endocrine Reviews·Stephanie T PageWilliam J Bremner

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Citations

Nov 30, 2010·International Journal of Endocrinology·Chunjiong WangJichun Yang
Dec 18, 2013·Women's Health·Jürgen HarreiterAlexandra Kautzky-Willer
Nov 1, 2011·Current Diabetes Reports·Shannon D SullivanRobert Ratner
Sep 21, 2013·Expert Opinion on Drug Discovery·Maliheh SafaviMohammad Abdollahi
Dec 18, 2012·European Journal of Clinical Investigation·Yvonne WinhoferAlexandra Kautzky-Willer
May 1, 2012·Medical Hypotheses·S W WenR Retnakaran
Apr 16, 2015·International Journal of Endocrinology·Yvonne WinhoferAlexandra Kautzky-Willer
Jun 3, 2011·Metabolism: Clinical and Experimental·Yong-ho LeeEun Seok Kang
Jan 29, 2011·Diabetes Care·Zachary T Bloomgarden
Nov 17, 2011·Gynecologic and Obstetric Investigation·Renata SaucedoErika Moreno
Jul 4, 2012·Nature Reviews. Endocrinology·Thomas A BuchananKathleen A Page
Aug 6, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·B AlmahmeedD S Feig
Apr 24, 2020·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Eyal SheinerMoshe Hod
Jan 5, 2017·The Korean Journal of Internal Medicine·Joon Ho MoonHak C Jang
May 12, 2017·Diabetes, Obesity & Metabolism·Tamara S HannonUNKNOWN RISE Consortium
Aug 16, 2017·Endocrine·Ida PastoreAntonio Brunetti
May 21, 2015·American Journal of Physiology. Endocrinology and Metabolism·Young Taek OhJang H Youn
May 17, 2017·Diabetes·Ravi Retnakaran
Jan 20, 2021·Revista brasileira de ginecologia e obstetrícia : revista da Federação Brasileira das Sociedades de Ginecologia e Obstetrícia·Patricia Moretti RehderBelmiro Gonçalves Pereira
Sep 10, 2019·Journal of Gynecology Obstetrics and Human Reproduction·Leila MeghelliPhilippe Deruelle
Sep 2, 2021·The Journal of Clinical Endocrinology and Metabolism·Karen L LindsayPathik D Wadhwa

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Methods Mentioned

BETA
ELISA

Software Mentioned

MINMOD

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