Declining Lung Function and Cardiovascular Risk: The ARIC Study

Journal of the American College of Cardiology
Odilson M SilvestreAmil M Shah

Abstract

Pulmonary dysfunction predicts incident cardiovascular disease (CVD). The purpose of this study was to evaluate whether longitudinal decline in lung function is associated with incident heart failure (HF), coronary heart disease (CHD), and stroke. Among 10,351 participants in the ARIC (Atherosclerosis Risk In Communities) study free of CVD, rapid lung function decline was defined as the greatest quartile (n = 2,585) of decline in either forced expiratory volume in 1 s (FEV1) (>1.9% decline/year) or forced vital capacity (FVC) (>2.1% decline/year) over 2.9 ± 0.2 years. The relationship between rapid decline in FEV1 or FVC and subsequent incident HF, CHD, stroke, or a composite of these was assessed using multivariable Cox regression adjusting for the baseline spirometry value, demographics, height, body mass index, heart rate, diabetes, hypertension, low-density lipoprotein, use of lipid-lowering medication, N-terminal fragment of prohormone for B-type natriuretic peptide, and smoking. The mean age was 54 ± 6 years, 56% were women, and 81% were white. At 17 ± 6 years of follow-up, HF occurred in 14%, CHD 11%, stroke 6%, and the composite in 24%. Rapid decline in FEV1 and in FVC were both associated with a heightened risk of inci...Continue Reading

Citations

Jun 17, 2020·Journal of Atherosclerosis and Thrombosis·Tomonori SugiuraNobuyuki Ohte
Dec 20, 2018·American Journal of Respiratory and Critical Care Medicine·Giuseppe Verlato, Mario Olivieri
Sep 30, 2020·Journal of Clinical Medicine·Kazuto MatsunagaTsunahiko Hirano
Dec 4, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Hannah R WhittakerJennifer K Quint
Dec 4, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Shaozhao ZhangXinxue Liao
Jan 15, 2020·Trends in Cardiovascular Medicine·Sergio H R Ramalho, Amil M Shah
Sep 26, 2020·The European Respiratory Journal·Hannah R WhittakerJennifer K Quint
Aug 21, 2021·Chest·Marc W HeidornJürgen H Prochaska
Jan 18, 2022·Current Cardiology Reports·Joscilin Mathew, Nils Patrick Nickel

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