Declining physical capacity but maintained aerobic activity in early Alzheimer's disease

American Journal of Alzheimer's Disease and Other Dementias
Ylva CedervallAnna Cristina Aberg

Abstract

The longitudinal influences on physical capacity and habitual aerobic activity level in the early stages of Alzheimer's disease (AD) are unclear. Therefore, changes in physical capacity and aerobic activity level were evaluated. Twenty-five individuals with AD were assessed annually for 2 years, by 10-m walk test, 6-minute walk test, and timed up-and-go (TUG) single/dual tasks. Habitual aerobic activity was assessed by diary registrations. The AD group showed a lower physical capacity than controls at baseline but comparable levels of aerobic activity. During the follow-up period, physical capacity declined in the AD group, but the aerobic activity levels changed only marginally. Our results show that in the early stages of AD, people are capable of maintaining health-promoting aerobic activity levels, despite a decline in their physical capacity. Additionally, it appears that cognitive dysfunction contributes to an impaired physical capacity. The TUG tasks might, therefore, be useful for detecting early signs of cognitive impairment.

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Feb 1, 1991·Journal of the American Geriatrics Society·D Podsiadlo, S Richardson
Sep 19, 2000·Medicine and Science in Sports and Exercise·B E AinsworthA S Leon
Jun 26, 2001·Journal of Advanced Nursing·W JanssonM Grafström
May 15, 2002·Dementia and Geriatric Cognitive Disorders·Anna F PetterssonLars-Olof Wahlund
Oct 31, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Jonathan F BeanWalter Frontera
Dec 23, 2003·Journal of the American Geriatrics Society·Pamela L SheridanJeffrey M Hausdorff
Oct 7, 2004·Archives of Physical Medicine and Rehabilitation·Patricia HeynKenneth J Ottenbacher
Mar 24, 2005·Dementia and Geriatric Cognitive Disorders·A F PetterssonL-O Wahlund
May 3, 2005·Experimental Brain Research·Jeffrey M HausdorffNir Giladi
Dec 15, 2006·Lancet Neurology·Anke H SnijdersBastiaan R Bloem
Dec 22, 2006·Journal of Nursing Scholarship : an Official Publication of Sigma Theta Tau International Honor Society of Nursing·Fang YuPaul J Eslinger
Jan 9, 2007·Archives of Physical Medicine and Rehabilitation·Joe VergheseMarco Pahor
Mar 8, 2007·Journal of Geriatric Psychiatry and Neurology·Anna F PetterssonLars-Olof Wahlund
Jul 12, 2007·Dementia and Geriatric Cognitive Disorders·Pamela L Sheridan, Jeffrey M Hausdorff
Jul 17, 2007·Trends in Cognitive Sciences·Arthur F Kramer, Kirk I Erickson
Dec 21, 2007·Nature Reviews. Neuroscience·Charles H HillmanArthur F Kramer
Mar 5, 2008·Alzheimer Disease and Associated Disorders·Jeffrey M BurnsJoseph E Donnelly
Sep 5, 2008·JAMA : the Journal of the American Medical Association·Nicola T LautenschlagerOsvaldo P Almeida
Oct 9, 2008·Dementia and Geriatric Cognitive Disorders·Joanne E WittwerHylton B Menz
Mar 31, 2009·Physical Therapy·Fay B HorakJames Frank
Jan 13, 2010·Archives of Neurology·Laura D BakerSuzanne Craft
Feb 11, 2010·Journal of Neurology, Neurosurgery, and Psychiatry·Bernadette McGuinnessA Peter Passmore
Apr 13, 2010·Archives of Physical Medicine and Rehabilitation·Laura H EggermontRobert A Stern
Jun 18, 2010·Current Neurology and Neuroscience Reports·Nicola T LautenschlagerAlexander F Kurz
Jul 28, 2010·American Journal of Alzheimer's Disease and Other Dementias·Susan M McCurryLinda Teri
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Nikolaos ScarmeasYaakov Stern
Oct 29, 2010·Dementia and Geriatric Cognitive Disorders·Christiaan G BlankevoortErik J A Scherder
Feb 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Kirk I EricksonArthur F Kramer
Feb 25, 2011·Bulletin of the World Health Organization·Nir Eyal, Samia A Hurst
Mar 16, 2011·Archives of Neurology·Robert S WilsonDavid A Bennett
Mar 25, 2011·American Journal of Alzheimer's Disease and Other Dementias· Fang Yu
Jun 28, 2011·Archives of Physical Medicine and Rehabilitation·Michelle N McDonnellShylie F Mackintosh

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Citations

Mar 11, 2020·International Journal of Environmental Research and Public Health·Ylva CedervallAnna Cristina Åberg
Sep 13, 2020·International Journal of Environmental Research and Public Health·Yan HuangNelson Chun-Yiu Yeung
Oct 10, 2018·Journal of Aging and Physical Activity·Nicolas FarinaRuth G Lowry
Nov 7, 2020·International Journal of Environmental Research and Public Health·Hanna B ÅhmanAnna Cristina Åberg
Aug 11, 2020·Archives of Gerontology and Geriatrics·Pablo Tomas-CarusDaniel Collado-Mateo

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