Declining trend in HIV new infections in Guangxi, China: insights from linking reported HIV/AIDS cases with CD4-at-diagnosis data

BMC Public Health
Xiaodan SunYanni Xiao

Abstract

The Guangxi Zhuang Autonomous Region bears a relatively high burden of HIV/AIDS infection. The number of accumulatively reported HIV/AIDS cases in Guangxi is the third highest among 31 provinces or Autonomous Region from 2004 to 2007, changed to the second highest between 2011 and 2013, then returned to the third highest again after 2014. We aim to estimate the new infections and evaluate the real-time HIV epidemic in Guangxi, China, in order to reveal the rule of HIV transmission. Firstly, the number of annually reported HIV and AIDS cases, as well as the number of cases linked with CD4 data are extracted from the HIV/AIDS information system in China. Secondly, two CD4-staged models are formulated by linking the with-host information on CD4 level to between-host transmission and surveillance data. Thirdly, new HIV infections, diagnosis rates and undiagnosed infections over time are estimated by using Bayesian method and Maximum Likelihood Estimation method. The data reveal that the newly reported cases have been decreasing since 2011, while lots of cases are identified at late CD4 stage. The data fitted results indicate that both models can describe the trend of the epidemic well. The estimation results show that the new and u...Continue Reading

References

Oct 1, 1991·Statistics in Medicine·N G BeckerJ B Carlin
Oct 15, 1994·Statistics in Medicine·G M RaabG Allardice
May 8, 2000·Statistics in Medicine·J Cui, N G Becker
Nov 4, 2000·Journal of Psychoactive Drugs·S LaiX F Yu
Apr 24, 2001·Journal of Acquired Immune Deficiency Syndromes : JAIDS·S LaiX F Yu
Jun 10, 2006·Science·Zunyou WuRoger Detels
Feb 27, 2007·Lancet·Zunyou WuRoger Detels
Jul 11, 2008·Mathematical Biosciences and Engineering : MBE·Yican ZhouJianhong Wu
Jun 6, 2009·Sexually Transmitted Infections·J T F LauJ Zhang
Nov 21, 2009·The Lancet Infectious Diseases·Rebecca GuyUNKNOWN WHO Working Group on HIV Incidence Assays
Feb 10, 2010·Journal of Urban Health : Bulletin of the New York Academy of Medicine·Cui YangKenrad Nelson
Aug 21, 2012·Sexually Transmitted Diseases·Xi ChenKaveh Khoshnood
Sep 26, 2012·Sexually Transmitted Diseases·Kathleen H ReillyNing Wang
Nov 7, 2012·The Journal of Infectious Diseases·Oliver LaeyendeckerSusan H Eshleman
Feb 5, 2013·The Lancet Infectious Diseases·Paul J BirrellDaniela De Angelis
Jul 5, 2019·Current HIV Research·Huanhuan ChenWenmin Yang
Jan 23, 2020·Theoretical Biology & Medical Modelling·Xiaodan SunYanni Xiao

❮ Previous
Next ❯

Software Mentioned

rjags R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
X M GeY Q Deng
AIDS Research and Human Retroviruses
J ChenT D Mastro
International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Yong-Chao QiaoYe-Sheng Wei
© 2022 Meta ULC. All rights reserved