Decoding and encoding models reveal the role of mental simulation in the brain representation of meaning

Royal Society Open Science
David SotoRoberto Santana

Abstract

How the brain representation of conceptual knowledge varies as a function of processing goals, strategies and task-factors remains a key unresolved question in cognitive neuroscience. In the present functional magnetic resonance imaging study, participants were presented with visual words during functional magnetic resonance imaging (fMRI). During shallow processing, participants had to read the items. During deep processing, they had to mentally simulate the features associated with the words. Multivariate classification, informational connectivity and encoding models were used to reveal how the depth of processing determines the brain representation of word meaning. Decoding accuracy in putative substrates of the semantic network was enhanced when the depth processing was high, and the brain representations were more generalizable in semantic space relative to shallow processing contexts. This pattern was observed even in association areas in inferior frontal and parietal cortex. Deep information processing during mental simulation also increased the informational connectivity within key substrates of the semantic network. To further examine the properties of the words encoded in brain activity, we compared computer vision mo...Continue Reading

References

Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·S KapurG M Brown
Apr 17, 2001·The Behavioral and Brain Sciences·L W Barsalou
May 9, 2001·Psychological Science·R A Stanfield, R A Zwaan
Apr 6, 2002·Psychological Science·Rolf A ZwaanRichard H Yaxley
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Jan 27, 2007·Journal of Neuroscience Methods·Jonathan W Peirce
Jun 15, 2007·Journal of Experimental Psychology. Human Perception and Performance·David Soto, Glyn W Humphreys
Nov 21, 2007·Nature Reviews. Neuroscience·Karalyn PattersonTimothy T Rogers
May 31, 2008·Science·Tom M MitchellMarcel Adam Just
Dec 17, 2008·NeuroImage·Francisco PereiraMatthew Botvinick
Feb 3, 2009·Neuroinformatics·Michael HankeStefan Pollmann
Oct 10, 2009·Psychonomic Bulletin & Review·Diane PecherHendrik N J Schifferstein
Apr 28, 2010·NeuroImage·Sander M DaselaarCyriel M A Pennartz
Oct 27, 2010·NeuroImage·Svetlana V ShinkarevaMarcel Adam Just
Oct 8, 2011·Brain and Language·Augusto BuchweitzMarcel Adam Just
Oct 18, 2011·Trends in Cognitive Sciences·Jeffrey R Binder, Rutvik H Desai
Oct 16, 2012·Cerebral Cortex·Irina SimanovaMarcel A J van Gerven
Feb 14, 2013·Frontiers in Human Neuroscience·Marc N Coutanche, Sharon L Thompson-Schill
Mar 8, 2013·Behavior Research Methods·Andrew DuchonManuel Carreiras
May 21, 2013·Nature Neuroscience·Jeremy FreemanJ Anthony Movshon
Nov 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Barry J DevereuxLorraine K Tyler
Mar 17, 2015·NeuroImage·Raimon H R PruimChristian F Beckmann
Oct 2, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Najib J MajajJames J DiCarlo
Apr 1, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy Rose PriceRoy H Hamilton
Apr 29, 2016·Nature·Alexander G HuthJack L Gallant
Sep 23, 2016·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Leonardo FernandinoJeffrey R Binder
Nov 25, 2016·Nature Reviews. Neuroscience·Matthew A Lambon RalphTimothy T Rogers
Dec 19, 2016·NeuroImage·Gaël VaroquauxBertrand Thirion
Oct 12, 2017·Frontiers in Systems Neuroscience·Christopher R HoldgrafFrederic E Theunissen
Jan 7, 2018·Trends in Cognitive Sciences·Stefano Anzellotti, Marc N Coutanche
Aug 22, 2018·Nature Neuroscience·Nikolaus Kriegeskorte, Pamela K Douglas
Oct 2, 2019·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andrew James AndersonEdmund C Lalor

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Citations

Nov 22, 2020·Nature Communications·Andrew James AndersonFeng V Lin

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Methods Mentioned

BETA
PCA
feature extraction

Software Mentioned

MobilenetV2
learn
Adam
EsPal
brain extraction tool ( BET )
MCFLIRT
Keras
Tensorflow
ICA
Fast

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