Decoding Common Features of Neurodegenerative Disorders: From Differentially Expressed Genes to Pathways

Current Genomics
Rabia HabibNeha Nadeem

Abstract

Neurodegeneration is a progressive/irreversible loss of neurons, building blocks of our nervous system. Their degeneration gradually collapses the entire structural and functional system manifesting in myriads of clinical disorders categorized as Neurodegenerative Disorders (NDs) such as Alzheimer's Disease, (AD), Parkinson's Disease (PD), Frontotemporal Dementia (FTD) and Amyotrophic Lateral Sclerosis (ALS). NDs are characterized by a puzzling interplay of molecular and cellular defects affecting subset of neuronal populations in specific affected brain areas. In present study, comparative in silico analysis was performed by utilizing gene expression datasets of AD, PD, FTD and ALS to identify potential common features to gain insights into complex molecular pathophysiology of the selected NDs. Gene expression data of four disorders were subjected to the identification of Differential Gene Expression (DEG) and their mapping on biological processes, KEGG pathways and molecular functions. Detailed comparative analysis was performed to highlight the common grounds of these dis-orders at various stages. Astoundingly, 106 DEGs were found to be common across all disorders. Alongwith in total 100 GO terms and 7 KEGG pathways were fou...Continue Reading

Citations

Dec 11, 2019·Current Pharmaceutical Design·Y-H Taguchi, Turki Turki
Oct 18, 2019·Frontiers in Cellular Neuroscience·Suaad AhmedImke E Mulder
Feb 26, 2020·Neuropharmacology·Jordi ClarimonAgustín Ruiz
Apr 4, 2021·International Journal of Molecular Sciences·Daisy SprovieroCristina Cereda

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Datasets Mentioned

BETA
GSE56808

Methods Mentioned

BETA
chips
GTPase

Software Mentioned

STRINGS
miRNet
GEO query
GeneMania
CytoHubba
R
limma R
BioLayout3D
GEO2R
Bioconductor

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