Decoding errors and the involvement of the E-site

Biochimie
K H Nierhaus

Abstract

Life depends on the faithful translation of the genetic information into proteins. Ribosomes have developed remarkable mechanisms to ensure the accurate synthesis of proteins. In the first part of this review various types of ribosomal errors and their importance for cell-life are surveyed, while in the second part two important aspects of the ribosomal E-site for the accuracy of translation are considered: (i) The fact that usually misincorporations are not harmful for the cell, since only one in about 400 misincorporations will affect the structure and/or function of a protein, is a function of the E-site. (ii) In contrast, an extremely harmful translational error is a loss of the reading frame, resulting in an immediate loss of the genetic information. Maintenance of the reading frame is one of the most remarkable achievements of the ribosome; only once in about 30,000 elongation cycles is the reading frame lost. A cognate tRNA at the E-site is an essential prerequisite for this high precision.

Citations

Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Markus PechKnud H Nierhaus
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Chunlai ChenYale E Goldman
Mar 2, 2012·The Journal of Biological Chemistry·Alexandros D Petropoulos, Rachel Green
Sep 29, 2009·Nucleic Acids Research·Pei-Yu LiaoKelvin H Lee
Jan 24, 2014·Nucleic Acids Research·Heena KhatterBruno P Klaholz
Dec 28, 2010·Journal of Proteomics·Masahiro KamitaHisashi Hirano
Mar 25, 2009·Angewandte Chemie·Mathias Sprinzl
Jun 3, 2009·Molecular Microbiology·Tanel Tenson, Vasili Hauryliuk
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Feb 18, 2016·Journal of Molecular Biology·Qi Liu, Kurt Fredrick
Feb 26, 2009·Cell·Hani S Zaher, Rachel Green
Mar 30, 2016·Annual Review of Biochemistry·Basil J Greber, Nenad Ban
Apr 12, 2015·Genome Biology and Evolution·Eli O van der SluisRoland Beckmann
Mar 24, 2017·Nucleic Acids Research·Suna P GulayJonathan D Dinman
Mar 11, 2018·Biochemistry. Biokhimii︠a︡·T M Makarova, A A Bogdanov

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