Decoding inflammation, its causes, genomic responses, and emerging countermeasures.

Scandinavian Journal of Immunology
Jacek Hawiger, Jozef Zienkiewicz

Abstract

Inflammation is the mechanism of diseases caused by microbial, autoimmune, allergic, metabolic and physical insults that produce distinct types of inflammatory responses. This aetiologic view of inflammation informs its classification based on a cause-dependent mechanism as well as a cause-directed therapy and prevention. The genomic era ushered in a new understanding of inflammation by highlighting the cell's nucleus as the centre of the inflammatory response. Exogenous or endogenous inflammatory insults evoke genomic responses in immune and non-immune cells. These genomic responses depend on transcription factors, which switch on and off a myriad of inflammatory genes through their regulatory networks. We discuss the transcriptional paradigm of inflammation based on denying transcription factors' access to the nucleus. We present two approaches that control proinflammatory signalling to the nucleus. The first approach constitutes a novel intracellular protein therapy with bioengineered physiologic suppressors of cytokine signalling. The second approach entails control of proinflammatory transcriptional cascades by targeting nuclear transport with a cell-penetrating peptide that inhibits the expression of 23 out of the 26 medi...Continue Reading

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Citations

Jul 18, 2020·The Journal of Cell Biology·Manuel ChiusaAmbra Pozzi
Jul 23, 2020·Scandinavian Journal of Immunology·Lisa Lynn Ten BergenSilke Appel
Aug 1, 2020·Scandinavian Journal of Immunology·Paweł BorowiczAnne Spurkland
Nov 26, 2020·Journal of Fish Diseases·Jose Carlos Campos-Sánchez, María Ángeles Esteban
Jan 16, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Luna KrstićYolanda Diebold
Jan 21, 2021·International Journal of Molecular Sciences·Márcia V de CarvalhoAdriana R Silva
Dec 10, 2020·Clinical and Translational Allergy·Jean BousquetUNKNOWN ARIA group
Jun 22, 2021·Frontiers in Cell and Developmental Biology·Jiahui LuoKai Sun
Sep 22, 2021·Inflammation·Ariane R de F RochaSylvia do C C Franceschini
Oct 15, 2021·Molecular Biology Reports·Fatemeh SadoughiBahman Yousefi

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Methods Mentioned

BETA
nuclear translocation
bronchoalveolar lavage
ubiquitination
transgenic
dissect
GTPase
histone acetylation

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