Decoding negative affect personality trait from patterns of brain activation to threat stimuli

NeuroImage
Orlando FernandesJanaina Mourão-Miranda

Abstract

Pattern recognition analysis (PRA) applied to functional magnetic resonance imaging (fMRI) has been used to decode cognitive processes and identify possible biomarkers for mental illness. In the present study, we investigated whether the positive affect (PA) or negative affect (NA) personality traits could be decoded from patterns of brain activation in response to a human threat using a healthy sample. fMRI data from 34 volunteers (15 women) were acquired during a simple motor task while the volunteers viewed a set of threat stimuli that were directed either toward them or away from them and matched neutral pictures. For each participant, contrast images from a General Linear Model (GLM) between the threat versus neutral stimuli defined the spatial patterns used as input to the regression model. We applied a multiple kernel learning (MKL) regression combining information from different brain regions hierarchically in a whole brain model to decode the NA and PA from patterns of brain activation in response to threat stimuli. The MKL model was able to decode NA but not PA from the contrast images between threat stimuli directed away versus neutral with a significance above chance. The correlation and the mean squared error (MSE)...Continue Reading

References

Aug 1, 1991·Journal of Abnormal Psychology·L A Clark, D Watson
Jun 1, 1988·Journal of Personality and Social Psychology·D WatsonA Tellegen
Mar 1, 1994·Journal of Behavior Therapy and Experimental Psychiatry·M M Bradley, P J Lang
May 11, 1999·Trends in Cognitive Sciences·R J Davidson, W Irwin
Mar 21, 2001·Behavioral Neuroscience·T CanliJ D Gabrieli
Sep 29, 2001·Science·P E DowningN Kanwisher
Jun 22, 2002·Science·Turhan CanliJohn D E Gabrieli
Jun 20, 2003·NeuroImage·Fanny EugèneMario Beauregard
Apr 15, 2004·Current Opinion in Neurobiology·Stephan Hamann, Turhan Canli
Nov 19, 2004·Social Psychiatry and Psychiatric Epidemiology·Johan OrmelAnn Farmer
Jan 6, 2005·Journal of Personality and Social Psychology·Kristian E MarkonDavid Watson
Apr 27, 2005·Nature Neuroscience·John-Dylan Haynes, Geraint Rees
Apr 27, 2005·Nature Neuroscience·Yukiyasu Kamitani, Frank Tong
Jul 9, 2005·Current Opinion in Neurology·Stefan Wiens
Sep 27, 2005·Cognitive, Affective & Behavioral Neuroscience·Naomi I EisenbergerAjay B Satpute
Nov 18, 2005·Neuroscience and Biobehavioral Reviews·Sarah WhittleMurat Yücel
Nov 18, 2005·Brain Research. Cognitive Brain Research·Michael X CohenCharan Ranganath
Dec 24, 2005·Science·Sean M PolynKenneth A Norman
Feb 14, 2006·Depression and Anxiety·Thilo DeckersbachScott L Rauch
Feb 13, 2007·Current Biology : CB·John-Dylan HaynesRichard E Passingham
Apr 17, 2007·Psychophysiology·Margaret M BradleyPeter J Lang
Oct 19, 2007·Psychiatry Research·Jennifer C BrittonIsrael Liberzon
Jun 25, 2008·Neuropsychologia·Christine I HookerMark D'Esposito
Apr 24, 2009·Psychophysiology·Laura A S OliveiraEliane Volchan
Oct 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Dean MobbsChristopher D Frith
Mar 17, 2010·Current Biology : CB·Martin J ChadwickEleanor A Maguire
Mar 30, 2010·NeuroImage·Cynthia M StonningtonUNKNOWN Alzheimer Disease Neuroimaging Initiative
Jun 1, 2010·NeuroImage·Thorsten KahntJohn-Dylan Haynes
Sep 11, 2010·Science·Nico U F DosenbachBradley L Schlaggar
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Dean MobbsTim Dalgleish

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Citations

Dec 25, 2016·NeuroImage·Vince D CalhounKlaas E Stephan
Jul 27, 2017·Human Brain Mapping·Lili WangChunliang Feng
Aug 26, 2019·Brain Imaging and Behavior·Orlando FernandesLetícia Oliveira
Jun 11, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Geraldo Busatto FilhoFabio L Duran

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Software Mentioned

Statistical Parametric Mapping
SPM8
PRoNTo
Neurobehavioral Systems

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