Decoding sequential finger movements from preparatory activity in higher-order motor regions: a functional magnetic resonance imaging multi-voxel pattern analysis

The European Journal of Neuroscience
Isao NambuEiichi Naito

Abstract

Performing a complex sequential finger movement requires the temporally well-ordered organization of individual finger movements. Previous behavioural studies have suggested that the brain prepares a whole sequence of movements as a single set, rather than the movements of individual fingers. However, direct neuroimaging support for this hypothesis is lacking and, assuming it to be true, it remains unclear which brain regions represent the information of a prepared sequence. Here, we measured brain activity with functional magnetic resonance imaging while 14 right-handed healthy participants performed two types of well-learned sequential finger movements with their right hands. Using multi-voxel pattern analysis, we examined whether the types of the forthcoming sequence could be predicted from the preparatory activities of nine regions of interest, which included the motor, somatosensory and posterior parietal regions in each hemisphere, bilateral visual cortices, cerebellum and basal ganglia. We found that, during preparation, the activity of the contralateral motor regions could predict which of the two sequences would be executed. Further detailed analysis revealed that the contralateral dorsal premotor cortex and supplement...Continue Reading

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Citations

Aug 9, 2020·Scientific Reports·Kasper Winther AndersenHartwig Roman Siebner
Jan 2, 2021·NeuroImage·Tyler J Adkins, Taraz G Lee
Jun 26, 2021·Neuroscience Letters·Yuki H HamanoNorihiro Sadato

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