Decoding the distribution of glycan receptors for human-adapted influenza A viruses in ferret respiratory tract.

PloS One
Akila JayaramanRam Sasisekharan

Abstract

Ferrets are widely used as animal models for studying influenza A viral pathogenesis and transmissibility. Human-adapted influenza A viruses primarily target the upper respiratory tract in humans (infection of the lower respiratory tract is observed less frequently), while in ferrets, upon intranasal inoculation both upper and lower respiratory tract are targeted. Viral tropism is governed by distribution of complex sialylated glycan receptors in various cells/tissues of the host that are specifically recognized by influenza A virus hemagglutinin (HA), a glycoprotein on viral surface. It is generally known that upper respiratory tract of humans and ferrets predominantly express α2→6 sialylated glycan receptors. However much less is known about the fine structure of these glycan receptors and their distribution in different regions of the ferret respiratory tract. In this study, we characterize distribution of glycan receptors going beyond terminal sialic acid linkage in the cranial and caudal regions of the ferret trachea (upper respiratory tract) and lung hilar region (lower respiratory tract) by multiplexing use of various plant lectins and human-adapted HAs to stain these tissue sections. Our findings show that the sialylate...Continue Reading

References

Mar 14, 1991·European Journal of Biochemistry·J M PeriniP Roussel
Jun 5, 1995·FEBS Letters·A S GambaryanM N Matrosovich
Sep 1, 1994·The European Respiratory Journal·M L Lohmann-MatthesG Franke-Ullmann
Nov 23, 2000·Journal of Virology·Y SuzukiY Kawaoka
Apr 9, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mikhail N MatrosovichHans-Dieter Klenk
Oct 1, 2004·Lab Animal·John A Maher, Joanne DeStefano
Mar 24, 2006·Nature·Kyoko ShinyaYoshihiro Kawaoka
Mar 25, 2006·Science·Debby van RielThijs Kuiken
Aug 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·Taronna R MainesJacqueline M Katz
Oct 3, 2006·Nature Reviews. Microbiology·James StevensIan A Wilson
Nov 23, 2006·Methods in Enzymology·Ola Blixt, Nahid Razi
Aug 25, 2007·The American Journal of Pathology·Keith G Mansfield
Jan 8, 2008·Nature Biotechnology·Aarthi ChandrasekaranRam Sasisekharan
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aravind SrinivasanRam Sasisekharan
Dec 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tokiko WatanabeYoshihiro Kawaoka
Mar 6, 2010·The American Journal of Pathology·Adolfo García-Sastre
Aug 25, 2010·Glycoconjugate Journal·Karthik ViswanathanRam Sasisekharan
Nov 10, 2010·PloS One·Karthik ViswanathanRam Sasisekharan
Jan 7, 2011·The Journal of Infectious Diseases·Matthew J MemoliJeffery K Taubenberger
Aug 4, 2011·Disease Models & Mechanisms·Jessica A BelserTerrence M Tumpey

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Citations

Nov 23, 2013·Virology Journal·Miriam CohenPascal Gagneux
Apr 24, 2012·Trends in Microbiology·Kortney M GustinTaronna R Maines
Jul 6, 2014·The Journal of General Virology·Stephen S H HuangDavid J Kelvin
Dec 18, 2014·Nature Communications·Preston S K NgMichael P Jennings
May 15, 2013·PLoS Pathogens·Teagan GuarnacciaKaren L Laurie
Jun 12, 2013·Cell·Kannan TharakaramanRam Sasisekharan
Nov 12, 2016·ELife·Marc LipsitchColin A Russell
Feb 22, 2017·Journal of Immunological Methods·Daniel S LaytonTimothy E Adams
Apr 12, 2020·Vaccines·Amanda L Skarlupka, Ted M Ross
Dec 25, 2019·Cold Spring Harbor Perspectives in Medicine·Jessica A BelserTaronna R Maines
Nov 8, 2018·Scientific Reports·Juliane MayrThomas Haselhorst
Feb 12, 2021·Viruses·Suresh V KuchipudiMurugan Subbiah
Dec 8, 2017·Journal of Virology·Kiyoko Iwatsuki-HorimotoYoshihiro Kawaoka
Jun 3, 2021·Viruses·Thi-Quyen NguyenYoung-Ki Choi
Aug 7, 2021·Vaccines·Ericka Kirkpatrick Roubidoux, Stacey Schultz-Cherry

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