Decoding the Emerging Patterns Exhibited in Non-coding RNAs Characteristic of Lung Cancer with Regard to their Clinical Significance

Current Genomics
Laura SoneaIoana Berindan-Neagoe

Abstract

Lung cancer continues to be the leading topic concerning global mortality rate caused by can-cer; it needs to be further investigated to reduce these dramatic unfavorable statistic data. Non-coding RNAs (ncRNAs) have been shown to be important cellular regulatory factors and the alteration of their expression levels has become correlated to extensive number of pathologies. Specifically, their expres-sion profiles are correlated with development and progression of lung cancer, generating great interest for further investigation. This review focuses on the complex role of non-coding RNAs, namely miR-NAs, piwi-interacting RNAs, small nucleolar RNAs, long non-coding RNAs and circular RNAs in the process of developing novel biomarkers for diagnostic and prognostic factors that can then be utilized for personalized therapies toward this devastating disease. To support the concept of personalized medi-cine, we will focus on the roles of miRNAs in lung cancer tumorigenesis, their use as diagnostic and prognostic biomarkers and their application for patient therapy.

Citations

May 6, 2019·Cancers·Cornelia BraicuIoana Berindan-Neagoe
Jan 1, 2020·Current Gene Therapy·Luis María Vaschetto
Dec 15, 2018·Molecular Oncology·Cornelia BraicuIoana Berindan-Neagoe
Apr 23, 2020·Frontiers in Oncology·Alina-Andreea ZimtaIoana Berindan-Neagoe
Oct 8, 2020·International Journal of Molecular Sciences·Marina Dudea-SimonIoana Berindan-Neagoe
Jan 30, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Rares DrulaIoana Berindan-Neagoe

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Methods Mentioned

BETA
biopsy
xenografts
antisense
xenograft
antisense oligonucleotides

Software Mentioned

circRNA

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