PMID: 16532934Mar 15, 2006Paper

Decomposition analysis of differential dose volume histograms

Medical Physics
Frank Van den Heuvela

Abstract

Dose volume histograms are a common tool to assess the value of a treatment plan for various forms of radiation therapy treatment. The purpose of this work is to introduce, validate, and apply a set of tools to analyze differential dose volume histograms by decomposing them into physically and clinically meaningful normal distributions. A weighted sum of the decomposed normal distributions (e.g., weighted dose) is proposed as a new measure of target dose, rather than the more unstable point dose. The method and its theory are presented and validated using simulated distributions. Additional validation is performed by analyzing simple four field box techniques encompassing a predefined target, using different treatment energies inside a water phantom. Furthermore, two clinical situations are analyzed using this methodology to illustrate practical usefulness. A comparison of a treatment plan for a breast patient using a tangential field setup with wedges is compared to a comparable geometry using dose compensators. Finally, a normal tissue complication probability (NTCP) calculation is refined using this decomposition. The NTCP calculation is performed on a liver as organ at risk in a treatment of a mesothelioma patient with invo...Continue Reading

References

Dec 1, 1991·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·W P MaylesS Webb
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·G J KutcherR Mohan
May 15, 1991·International Journal of Radiation Oncology, Biology, Physics·R E DrzymalaM Urie
Sep 1, 1990·Medical Physics·A Niemierko, M Goitein
Jun 1, 1989·International Journal of Radiation Oncology, Biology, Physics·G J Kutcher, C Burman
Aug 1, 1987·International Journal of Radiation Oncology, Biology, Physics·M Langer, J Leong
Aug 1, 1981·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·A Cebulska-WasilewskaK H Chadwick
Jan 1, 1993·Medical Physics·X Q Lu, L M Chin
Oct 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·P M EvansJ R Yarnold
Jun 17, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C J McGinnT S Lawrence
Dec 30, 1998·International Journal of Radiation Oncology, Biology, Physics·T KnöösP Nilsson
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·A ArefG Ezzell
Jul 6, 2004·International Journal of Radiation Oncology, Biology, Physics·Jackie HarneyMichele I Saunders

❮ Previous
Next ❯

Citations

Feb 23, 2010·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Wouter CrijnsFrank Van den Heuvel
Jan 26, 2010·Medical Dosimetry : Official Journal of the American Association of Medical Dosimetrists·Katrien ErvenWalter Van den Bogaert
Jan 25, 2011·The Mount Sinai Journal of Medicine, New York·Michele La Merrill, Linda S Birnbaum
Sep 12, 2006·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kristina KontrisovaDietmar Georg
Oct 24, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Yongmei LiuFeng-Ming Spring Kong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.