Decomposition of methionine by low energy electrons

Physical Chemistry Chemical Physics : PCCP
Janina KopyraMichel Farizon

Abstract

In this work, we present the results from low energy (<12 eV) electron impact on isolated methionine, Met. We show that dissociative electron attachment is the operative mechanism for the sulfur content amino-acid fragmentation. The two most dominant fragments are attributed to the (Met-H)(-) and (C(4)NOH(5))(-) ions that are formed at energy below 2 eV. The formation of the latter anion is accompanied by the loss of neutral counterparts, which are most likely a water molecule and highly toxic methanethiol, CH(3)SH. Further fragments are associated with the damage at the sulfur end of the amino acid, producing the methyl sulfide anion CH(3)S(-) or sulfur containing neutrals. In the context of radiation induced damage to biological material at the nano-scale level, the present interest of methionine arises from the implication of the molecule in biological processes (e.g., S-adenosyl methionine for the stimulation of DNA methyltransferase reactions or protein synthesis).

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Citations

Feb 13, 2013·Physical Chemistry Chemical Physics : PCCP·Benjamin PuschniggStephan Denifl
Aug 15, 2019·Journal of Mass Spectrometry : JMS·Rebecca MeißnerStephan Denifl
Dec 16, 2020·The Journal of Chemical Physics·Dipayan ChakrabortySylwia Ptasińska

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