Deconstructing collagen piezoelectricity using alanine-hydroxyproline-glycine building blocks

Nanoscale
Sarah GuerinDamien Thompson

Abstract

Collagen piezoelectricity has been the focus of a large number of experimental and theoretical studies for over fifty years. Less is known about the piezoelectric properties of its building blocks, in particular but not limited to, proline and hydroxyproline. Spurred by the recent upsurge of interest in piezoelectricity in organic crystals including our own report of unprecedentedly high piezoelectricity in amino acid glycine, we predict and measure the piezoelectric properties of collagen subcomponents in single crystalline forms and the collagen-like alanine-hydroxyproline-glycine trimer peptide. We map the modulation of piezoelectric charge constants in collagen building blocks as the crystal symmetry is lowered and the molecule size increases, finding strong evidence for amino acid-level barcoding of collagen piezoelectricity that can in turn be tuned using very simple chemistry. The simple addition of an -OH group can increase piezoelectric constants by up to two orders of magnitude (d25 = 25 ± 5 pC N-1) as measured in Y-cut hydroxyproline crystals. The value is similar to that obtained from thermoelectrically poled commercial polyvinylidene di fluoride (PVDF) films. Overall, our findings support a simple block by block ap...Continue Reading

References

Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·S Chen-KiangS Udenfriend
Feb 14, 1979·Biochemical and Biophysical Research Communications·N Venkateswara Rao, E Adams
Aug 1, 1976·Biophysical Journal·E FukadaR Rinaldi
Apr 13, 1968·Nature·J C Anderson, C Eriksson
Dec 1, 1965·The Journal of Physical Chemistry·S Takashima, H P Schwan
Dec 1, 1996·The Journal of the Acoustical Society of America·B K HoffmeisterJ G Miller
Dec 2, 1998·Journal of Biochemistry·V NagarajanK Okuyama
Oct 15, 1996·Physical Review. B, Condensed Matter·G Kresse, J Furthmüller
Oct 28, 1996·Physical Review Letters·J P PerdewM Ernzerhof
Oct 13, 2001·Ultrasound in Medicine & Biology·P L KuoM L Li
Oct 2, 2004·Analytical and Bioanalytical Chemistry·Giuseppe Pezzotti
Jun 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Joseph P R O OrgelTim J Wess
Sep 7, 2006·Acta Crystallographica. Section C, Crystal Structure Communications·Mitsunobu DoiAkiko Asano
Feb 2, 2008·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·E Fukada
Mar 17, 2009·Medical Engineering & Physics·Andrew C Ahn, Alan J Grodzinsky
Aug 19, 2011·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Z TylczyńskiM Wiesner
Jan 17, 2012·The Journal of Physical Chemistry. B·Harish Kumar RaviMichele Cascella
May 15, 2012·Nature Nanotechnology·Byung Yang LeeSeung-Wuk Lee
May 25, 2012·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Bernard CapelleYves Epelboin
May 18, 2013·Physical Review Letters·Yuanming LiuJiangyu Li
Jun 25, 2014·Proceedings of the National Academy of Sciences of the United States of America·Yuanming LiuJiangyu Li
Sep 23, 2014·Advanced Drug Delivery Reviews·Marc A Fernandez-YagueManus J Biggs
Dec 17, 2014·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·S SathiskumarS Thamotharan
Jan 7, 2015·Physical Chemistry Chemical Physics : PCCP·Ben-Qiong LiuTao Gao
Sep 17, 2015·Angewandte Chemie·Ido AzuriLeeor Kronik
Dec 5, 2017·Nature Materials·Sarah GuerinDamien Thompson
Dec 9, 2017·Physical Review Letters·Shi Liu, R E Cohen
Jun 13, 2016·ACS Biomaterials Science & Engineering·Zhong ZhouMajid Minary-Jolandan
Jun 12, 2017·ACS Biomaterials Science & Engineering·Denise DenningBrian J Rodriguez

❮ Previous
Next ❯

Citations

Feb 28, 2020·Advanced Materials·Daeyeong KimSeung-Wuk Lee
Feb 16, 2019·Physical Review Letters·Sarah GuerinDamien Thompson
May 13, 2021·Nature Communications·Santu BeraEhud Gazit
Jul 15, 2021·Advanced Science·Sujoy Kumar GhoshHyunhyub Ko

❮ Previous
Next ❯

Methods Mentioned

BETA
X-Ray

Software Mentioned

Vienna Ab initio Simulation Package ( VASP )

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.