PMID: 32675845Jul 18, 2020Paper

DECONSTRUCTING EXTRAPLACENTAL MEMBRANES TO UNDERSTAND BACTERIAL CHORIOAMNIONITIS.

Transactions of the American Clinical and Climatological Association
David M Aronoff

Abstract

Bacterial chorioamnionitis is an intrauterine infection that occurs during pregnancy and involves the membranes that extend from the placenta to form the sac encasing the amniotic fluid and developing fetus. Chorioamnionitis is most commonly caused by bacteria that likely ascend from the vagina into the gravid uterus and can result in devastating complications such as preterm labor, membrane rupture, fetal stillbirth, or severe infection of the newborn. Surviving babies exposed to chorioamnionitis in utero have an increased risk of lifelong disability. Unfortunately, most chorioamnionitis is clinically silent unless a bad outcome occurs, which compels the need for better diagnostic, therapeutic, and preventive approaches. Our lab has a primary interest in defining the early steps in disease pathogenesis of bacterial chorioamnionitis, when microbes first make contact with the fetal membranes. Through team science, we are using organ-on-chip models of human fetal membranes to define host-microbe interactions critical to the development of chorioamnionitis and its complications.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Ryōikibetsu shōkōgun shirīzu
T Terao
Josanpu zasshi = The Japanese journal for midwife
N Shimada
Akusherstvo i ginekologii︠a︡
A P Kiriushchenkov
Anales de la Real Academia Nacional de Medicina
J A Clavero Núñez
Clinical Obstetrics and Gynecology
J MacVicar
© 2021 Meta ULC. All rights reserved