Deconstructing the Complexity of TGFβ Signaling in Hematopoietic Stem Cells: Quiescence and Beyond

Current Stem Cell Reports
Ashwini Hinge, Marie-Dominique Filippi

Abstract

The hematopoietic system is highly dynamic and must constantly produce new blood cells every day. Mature blood cells all derive from a pool of rare long-lived hematopoietic stem cells (HSCs) that are mostly quiescent but occasionally divide and self-renew in order to maintain the stem cell pool and continuous replenishment of mature blood cells throughout life. A tight control of HSC self-renewal, commitment to differentiation and maintenance of quiescence states is necessary for lifelong blood supply. Transforming growth factor-β (TGF-β) is a critical regulator hematopoietic cell functions. It is a potent inhibitor of hematopoietic cell growth. However, TGFβ functions are more complex and largely context-dependent. Emerging evidence suggests a role in aging, cell identity and cell fate decisions. Here, we will review the role of TGF-β and downstream signaling in normal HSC functions, in HSC quiescence and beyond.

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Citations

Mar 1, 2019·Leukemia·Alex BatallerGuillermo Garcia-Manero
Jan 22, 2020·The Journal of Clinical Investigation·Amit VermaRavi Kumar
Apr 29, 2019·Cancer Metastasis Reviews·Zhe Wang, Margot Zöller
Dec 14, 2018·International Journal of Molecular Sciences·Esther TamayoRamón Merino
Feb 23, 2019·Cellular and Molecular Life Sciences : CMLS·Antero SalminenAnu Kauppinen

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