Deconstructing the traditional Japanese medicine "Kampo": compounds, metabolites and pharmacological profile of maoto, a remedy for flu-like symptoms

NPJ Systems Biology and Applications
Akinori NishiHiroaki Kitano

Abstract

Pharmacological activities of the traditional Japanese herbal medicine (Kampo) are putatively mediated by complex interactions between multiple herbal compounds and host factors, which are difficult to characterize via the reductive approach of purifying major bioactive compounds and elucidating their mechanisms by conventional pharmacology. Here, we performed comprehensive compound, pharmacological and metabolomic analyses of maoto, a pharmaceutical-grade Kampo prescribed for flu-like symptoms, in normal and polyI:C-injected rats, the latter suffering from acute inflammation via Toll-like receptor 3 activation. In total, 352 chemical composition-determined compounds (CCDs) were detected in maoto extract by mass spectrometric analysis. After maoto treatment, 113 CCDs were newly detected in rat plasma. Of these CCDs, 19 were present in maoto extract, while 94 were presumed to be metabolites generated from maoto compounds or endogenous substances such as phospholipids. At the phenotypic level, maoto ameliorated the polyI:C-induced decrease in locomotor activity and body weight; however, body weight was not affected by individual maoto components in isolation. In accordance with symptom relief, maoto suppressed TNF-α and IL-1β, in...Continue Reading

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Citations

Nov 8, 2017·Metabolomics : Official Journal of the Metabolomic Society·Masahito UjiMasato Nagino
Jan 29, 2021·NPJ Systems Biology and Applications·Akinori NishiHiroaki Kitano
Feb 9, 2021·Frontiers in Cellular and Infection Microbiology·Md Arifur RahmanTomoyuki Honda
Apr 21, 2021·Journal of Natural Medicines·Sho SanechikaKatsuya Ohbuchi
Jun 16, 2021·Journal of Ethnopharmacology·Takashi MatsumotoMitsutoshi Setou

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Methods Mentioned

BETA
ELISA

Software Mentioned

CellDesigner
maoto

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