Deconstructing white matter connectivity of human amygdala nuclei with thalamus and cortex subdivisions in vivo.

Human Brain Mapping
Aslan Abivardi, Dominik R Bach

Abstract

Structural alterations in long-range amygdala connections are proposed to crucially underlie several neuropsychiatric disorders. While progress has been made in elucidating the function of these connections, our understanding of their structure in humans remains sparse and non-systematic. Harnessing diffusion-weighted imaging and probabilistic tractography in humans, we investigate connections between two main amygdala nucleus groups, thalamic nuclei, and cortex. We first parcellated amygdala into deep (basolateral) and superficial (centrocortical) nucleus groups, and thalamus into six subregions, using previously established protocols based on connectivity. Cortex was parcellated based on T1-weighted images. We found substantial amygdala connections to thalamus, with different patterns for the two amygdala nuclei. Crucially, we describe direct subcortical connections between amygdala and paraventricular thalamus. Different from rodents but similar to non-human primates, these are more pronounced for basolateral than centrocortical amygdala. Substantial white-matter connectivity between amygdala and visual pulvinar is also more pronounced for basolateral amygdala. Furthermore, we establish detailed connectivity profiles for bas...Continue Reading

References

Mar 5, 1976·Brain Research·E G Jones, H Burton
Sep 20, 1991·Science·L R Squire, S Zola-Morgan
Jul 1, 1990·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J P Mugler, J R Brookeman
Oct 10, 1983·The Journal of Comparative Neurology·J TiggesM Tigges
Jan 1, 1984·The Journal of Comparative Neurology·J P Aggleton, M Mishkin
Dec 20, 1984·The Journal of Comparative Neurology·D G Amaral, J L Price
Apr 15, 1980·The Journal of Comparative Neurology·W R Mehler
Jul 20, 1982·The Journal of Comparative Neurology·J TiggesS Anschel
Dec 25, 1995·The Journal of Comparative Neurology·S T Carmichael, J L Price
Jun 27, 1998·Progress in Neurobiology·A J McDonald
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Aug 25, 2001·Annual Review of Neuroscience·S Maren
Oct 31, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·T E J BehrensS M Smith
Dec 5, 2003·Cerebral Cortex·Bruce FischlAnders M Dale
Aug 31, 2004·Science·Marianne FyhnMay-Britt Moser
Sep 2, 2004·Proceedings of the National Academy of Sciences of the United States of America·H Johansen-BergP M Matthews
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·T E J Behrens, H Johansen-Berg
Nov 18, 2005·Trends in Cognitive Sciences·Patrik Vuilleumier
Mar 16, 2007·Information Processing in Medical Imaging : Proceedings of the ... Conference·Florent SégonneBruce Fischl
Apr 10, 2007·Annual Review of Neuroscience·H EichenbaumC Ranganath
Dec 15, 2007·Cerebral Cortex·Bruce FischlKarl Zilles
Feb 1, 2008·Brain : a Journal of Neurology·Natalia M KleinhansElizabeth Aylward
Mar 4, 2008·The Journal of Comparative Neurology·Robert P Vertes, Walter B Hoover
Sep 5, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andreas MarschnerChristian Büchel
Sep 18, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Justin Kim, Paul J Whalen
Sep 29, 2009·Nature Neuroscience·Rebecca M Todd, Adam K Anderson
Apr 16, 2010·Annals of the New York Academy of Sciences·Ralph Adolphs
Apr 20, 2010·NeuroImage·Catherine TraynorMark P Richardson

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Citations

Feb 5, 2019·Journal of Neuropsychology·Caterina BertiniCristina Scarpazza
Dec 14, 2018·Journal of Neural Engineering·Reza AbiriXiaopeng Zhao
Dec 22, 2017·Human Brain Mapping·Clare R GibbardChris A Clark
Jul 28, 2020·Frontiers in Behavioral Neuroscience·Ausaf A BariNader Pouratian
Oct 20, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Zhida ZhangYongzhan Nie
Dec 4, 2020·Human Brain Mapping·Melanie A Matyi, Jeffrey M Spielberg
Dec 19, 2020·NeuroImage·Krzysztof BielskiIwona Szatkowska
Feb 20, 2021·Journal of Neuroscience Research·Jared J TannerKimberly T Sibille
Aug 20, 2018·NeuroImage·Juan Eugenio IglesiasPedro M Paz-Alonso
Jun 25, 2021·Neuron·Philip A KragelTor D Wager
Aug 28, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elisabeth A Murray, Lesley K Fellows

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Software Mentioned

probtrackx
HCP
FreeSurfer
FMRIB Software Library ( FSL )
SPM8
bedpostx
Matlab
SPSS
FSLView

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