Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment.

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
V P AndreevJulio Licinio

Abstract

Minimally invasive methodology, mathematical model, and software for analysis of glucose homeostasis by deconvolution of insulin secretion, hepatic extraction, post-hepatic delivery, and sensitivity from 24-hour standardized meals test have been developed and illustrated by the study of glucose homeostasis of a genetically based leptin-deficient patient before and after leptin replacement treatment. The only genetically leptin-deficient adult man identified in the world was treated for 24 months with recombinant methionyl human leptin. Blood was collected every 7 minutes for 24 hours, with standardized meals consumed during the 4 visits: at baseline, one-week, 18-months, and 24-months after initiation of the treatment. Concentrations of insulin, C-peptide, and plasma glucose were measured. Insulin secretion was obtained by deconvolution of C-peptide data. Hepatic insulin extraction was determined based on our modifications of the insulin kinetics model . Insulin sensitivity for each of the four meals was calculated by using the minimal glucose model approach. Hepatic extraction of insulin was the first element of glucose homeostasis to respond to leptin replacement treatment and increased 2-fold after one week of treatment. Ins...Continue Reading

Associated Clinical Trials

Apr 14, 2008·Richard BookmanRichard Bookman

Citations

May 12, 2012·The Cerebellum·Steven M BermanEdythe D London
Oct 16, 2008·American Journal of Physiology. Endocrinology and Metabolism·Gilberto Paz-FilhoJulio Licinio
Apr 8, 2009·The Journal of Clinical Endocrinology and Metabolism·Christos S Mantzoros
Apr 9, 2013·Indian Journal of Endocrinology and Metabolism·Gilberto Paz-FilhoJulio Licinio
Apr 9, 2013·Indian Journal of Endocrinology and Metabolism·Uma SinhaPrasanta Mukhopadhyay
Mar 12, 2013·Endocrine Reviews·Hyun-Seuk MoonChristos S Mantzoros
Apr 3, 2012·Biochimie·Camille VatierCorinne Vigouroux
Jan 1, 2016·Cell Death & Disease·Y Poloz, V Stambolic
Mar 18, 2011·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·G Paz-FilhoJ Licinio
Oct 1, 2014·Metabolism: Clinical and Experimental·Michael A TsoukasChristos S Mantzoros
Aug 27, 2014·Metabolism: Clinical and Experimental·Gilberto Paz-FilhoJulio Licinio
Aug 21, 2014·PloS One·Silvia CorrochanoAbraham Acevedo-Arozena
Feb 23, 2011·Arquivos brasileiros de endocrinologia e metabologia·Gilberto Paz-FilhoJulio Licinio
Aug 8, 2018·Endocrinology·Daniel FergusonCharles A Harris
Jul 12, 2018·Hormone Research in Pædiatrics·Christian L RothMartin Wabitsch

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