Deconvolved electrical impedance spectra track distinct cell morphology changes

IEEE Transactions on Bio-medical Engineering
D A McRae, M A Esrick

Abstract

A two-component Cole-Cole model was used to obtain statistically significant fits to 100-Hz-10-MHz impedance data for EMT-6 mouse tumors during the progressive histological changes induced by hyperthermia. The resulting fitting parameters were used to deconvolute and reconstruct the two dispersions which confer the predominant impedance features to this tissue. The time-dependent changes of these two dispersions were correlated with the concurrent, heat-induced morphological changes of the tumors' cells. The higher frequency dispersion (fc approximately 1 MHz) was identified with a Maxwell-Wagner relaxation process linked to the overall volume response of the cells. The lower frequency dispersion (fc approximately 10 kHz) represented an alpha-relaxation associated with the surface morphology and integrity of the plasma membranes. Thus, two aspects of the characteristic cellular damage sequence in these tumors were found to be separately discernable and trackable in real-time using the impedance data.

References

Nov 1, 1992·Physics in Medicine and Biology·D A McRae, M A Esrick
Jan 1, 1992·Annals of Biomedical Engineering·J R Macdonald
Jan 1, 1991·Annals of Biomedical Engineering·T Ragheb, L A Geddes
Nov 1, 1990·Physics in Medicine and Biology·L A Dissado
Oct 1, 1985·Physics in Medicine and Biology·A SurowiecA Swarup
Apr 1, 1982·Physics in Medicine and Biology·R D StoyH P Schwan
Feb 1, 1980·Cancer·L F FajardoG M Hahn
Jun 1, 1995·Physics in Medicine and Biology·L A DissadoM A Esrick
Aug 1, 1994·IEEE Transactions on Bio-medical Engineering·B H BrownA D Leathard
Mar 1, 1994·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K D PaulsenT P Ryan
Jul 30, 1951·Acta Physiologica Scandinavica·B ANDERSSON
Jun 1, 1994·Physics in Medicine and Biology·T TamuraH P Schwan

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Citations

Mar 4, 2000·Medical & Biological Engineering & Computing·S KunR M Dunn
Mar 21, 2000·Medical & Biological Engineering & Computing·S Kun, R A Peura
Mar 31, 1999·International Journal of Radiation Oncology, Biology, Physics·D A McRaeS C Mueller
Jan 1, 1997·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·D A McRaeS C Mueller
Nov 14, 1997·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K D Paulsen, H Jiang
Sep 1, 1996·International Journal of Hyperthermia : the Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·K D PaulsenP J Hoopes
Jun 18, 1999·Annals of the New York Academy of Sciences·J Jossinet, M Schmitt
Jan 26, 2000·IEEE Transactions on Bio-medical Engineering·A HartovK D Paulsen
Dec 6, 2003·IEEE Transactions on Bio-medical Engineering·Stevan KunRaymond M Dunn
Apr 9, 2004·Physics in Medicine and Biology·K Sunshine OstermanKeith D Paulsen
Jun 5, 1999·Journal of Medical Engineering & Technology·B BladK Lindström
Apr 5, 2013·Physics in Medicine and Biology·Tong In OhEung Je Woo

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