Decorated macrocycles via ring-closing double-reductive amination. identification of an apoptosis inducer of leukemic cells that at least partially antagonizes a 5-HT2 receptor

Organic Letters
Jian ZhouPaul V Murphy

Abstract

A build-couple-pair strategy, including double-reductive amination macrocyclization, has been used to generate decorated macrocycles (eannaphanes) with an embedded triazole and monosaccharide. Biological screening led to the identification of an inducer of apoptosis in leukemic cells, which acts at least partially as a 5-HT2 antagonist.

References

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Citations

Jan 18, 2016·Carbohydrate Research·Ankita SinghAshok K Prasad
Mar 5, 2019·Current Medicinal Chemistry·Kartikey Singh, Rama Pati Tripathi

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis