Decorin is a secreted protein associated with obesity and type 2 diabetes

International Journal of Obesity : Journal of the International Association for the Study of Obesity
Kristy BoltonKen Walder

Abstract

To characterize the expression of the small leucine-rich glycoprotein decorin in adipose tissue. Real-time PCR was used to measure decorin gene expression in adipose tissue from normal glucose tolerant (NGT), impaired glucose tolerant and type 2 diabetic (T2D) Psammomys obesus. Adipose tissue was fractionated to determine which cells were responsible for decorin expression. The location of decorin protein expression in adipose tissue was determined using immunohistochemistry. Real-time PCR was used to measure decorin mRNA levels in human adipose tissue from 16 insulin-sensitive, 16 insulin-resistant and 6 T2D human subjects. Circulating plasma decorin concentrations were measured by enzyme-linked immunosorbent assay in 145 NGT and 141 T2D human individuals from a large-scale epidemiological study in Mauritius. Decorin mRNA was found to be highly expressed in adipose tissue, and decorin gene expression was significantly higher in visceral than that in subcutaneous adipose tissue depots in both P. obesus and human subjects (P=0.002 and P=0.001, respectively). Decorin mRNA was predominantly expressed by stromal/vascular cells of adipose tissue, and decorin protein in adipose tissue was primarily detected adjacent to blood vessels....Continue Reading

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Citations

Feb 9, 2013·Experimental & Molecular Medicine·Mi-Hyun ParkJong-Young Lee
Jul 29, 2009·International Journal of Obesity : Journal of the International Association for the Study of Obesity·K BoltonK Walder
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Simone BuraschiRenato V Iozzo
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