Decorin promotes plasminogen/plasmin expression within acute spinal cord injuries and by adult microglia in vitro

Journal of Neurotrauma
Jeannette E DaviesStephen J Davies

Abstract

Spinal cord scar tissue presents a combined physical and molecular barrier to axon regeneration. Theoretically, spinal cord injuries (SCIs) can be rendered more permissive to axon growth by either suppressing synthesis of misaligned, fibrotic scar tissue and associated axon growth inhibitors, or enzymatically degrading them. We have previously shown that acute infusion of human recombinant decorin core protein into discreet stab injuries of the rat dorsal column pathways effected a major suppression of inflammation, astrogliosis, and multiple axon growth inhibitory chondroitin sulfate proteoglycans, which combined to promote rapid axon growth across the injury site. The high efficiency of chondroitin sulfate proteoglycan (CSPG) core protein suppression (approximately 90%) suggested that decorin may promote CSPG degradation in addition to suppressing CSPG synthesis. As the serine protease plasmin can degrade axon growth inhibitory CSPGs (neurocan and phosphacan) and its zymogen, plasmininogen is synthesized by microglia, we have investigated whether decorin treatment of acute SCIs and cultured adult spinal cord microglia can increase plasminogen/ plasmin synthesis. Infusion of hr-decorin over the first 8 days post-SCI induced 10...Continue Reading

References

Dec 4, 1992·Annals of the New York Academy of Sciences·G MurphyJ J Reynolds
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D HantaïB W Festoff
Apr 1, 1989·The Journal of Experimental Medicine·P H HartJ A Hamilton
Jan 1, 1987·Annual Review of Cell Biology·G R Martin, R Timpl
Aug 1, 1980·Annals of Neurology·E R FeringaH L Vahlsing
Aug 1, 1993·The Journal of Clinical Investigation·A P SappinoJ D Vassalli
Jan 1, 1997·Journal of Neuroscience Research·A G Rabchevsky, W J Streit
Oct 17, 1998·Glia·K NakajimaS Kohsaka
Jan 9, 1999·Trends in Neurosciences·S J Davies, J Silver
Oct 3, 1999·Experimental Neurology·A LoganM Berry
Jan 20, 2000·Trends in Cardiovascular Medicine·K A Hajjar, S Krishnan
Feb 24, 2001·Cellular and Molecular Life Sciences : CMLS·J P IrigoyenY Nagamine
Sep 1, 2001·Cellular and Molecular Life Sciences : CMLS·F D Miller, D R Kaplan
Nov 14, 2001·The Journal of Cell Biology·S MechtersheimerP Altevogt
Dec 1, 2001·Science·R LeeB L Hempstead
Apr 5, 2002·Journal of Neuroscience Research·Ward PlunetWolfram Tetzlaff
Apr 12, 2002·Nature·Elizabeth J BradburyStephen B McMahon
Jul 20, 2002·Journal of Neuropathology and Experimental Neurology·P G PopovichD M Basso
Feb 19, 2003·Brain Research. Brain Research Reviews·Marion MurrayI Fischer

❮ Previous
Next ❯

Citations

Jul 19, 2013·Neuroscience Bulletin·Yi-Min Yuan, Cheng He
Apr 27, 2012·PloS One·Carmen María Fernández-MartosFrancisco Javier Rodriguez
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Noreen BukhariStella E Tsirka
Dec 14, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Guillermo García-AlíasVictor L Arvanian
Jun 25, 2014·Neuroscience Bulletin·Dingding ShenXiaosong Gu
Jul 1, 2014·The American Journal of Pathology·Thomas NeillRenato V Iozzo
Nov 11, 2008·Analytical Biochemistry·Zhenqing ZhangRobert J Linhardt
Jul 22, 2008·Neurobiology of Disease·Kenneth MinorStephen J Davies
Aug 19, 2015·Experimental Neurology·Patrice D SmithJames W Fawcett
Aug 7, 2008·Journal of Neuroscience Research·Marcelo R VargasLuis Barbeito
Jan 21, 2014·Neuropathology and Applied Neurobiology·E R Burnside, E J Bradbury
May 13, 2014·Cell Transplantation·Wise Young
Nov 15, 2007·Glia·Westley B NolinStella E Tsirka
Jul 25, 2021·International Journal of Molecular Sciences·Shermaine W Y LowShyam S Chaurasia

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.