Decoupled temporal variability and signal synchronization of spontaneous brain activity in loss of consciousness: An fMRI study in anesthesia

NeuroImage
Zirui HuangGeorg Northoff

Abstract

Two aspects of the low frequency fluctuations of spontaneous brain activity have been proposed which reflect the complex and dynamic features of resting-state activity, namely temporal variability and signal synchronization. The relationship between them, especially its role in consciousness, nevertheless remains unclear. Our study examined the temporal variability and signal synchronization of spontaneous brain activity, as well as their relationship during loss of consciousness. We applied an intra-subject design of resting-state functional magnetic resonance imaging (rs-fMRI) in two conditions: during wakefulness, and under anesthesia with clinical unconsciousness. In addition, an independent group of patients with disorders of consciousness (DOC) was included in order to test the reliability of our findings. We observed a global reduction in the temporal variability, local and distant brain signal synchronization for subjects during anesthesia. Importantly, we found a link between temporal variability and both local and distant signal synchronizations during wakefulness: the higher the degree of temporal variability, the higher its intra-regional homogeneity and inter-regional functional connectivity. In contrast, this link...Continue Reading

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Citations

Jul 22, 2018·Anesthesiology·Lynn UhrigBechir Jarraya
Jul 18, 2017·Frontiers in Computational Neuroscience·Minkyung KimUnCheol Lee
Dec 8, 2017·Journal of Neurophysiology·Alexis T BariaA Vania Apkarian
Oct 15, 2019·Frontiers in Human Neuroscience·Georg Northoff
Nov 2, 2018·European Psychiatry : the Journal of the Association of European Psychiatrists·Angela V SpalatroGeorg Northoff
Jan 14, 2017·Frontiers in Neural Circuits·MohammadMehdi KafashanBen J A Palanca
Jul 6, 2018·Human Brain Mapping·Zirui HuangGeorg Northoff
Mar 21, 2020·Science Advances·Zirui HuangAnthony G Hudetz
Mar 20, 2019·Frontiers in Psychiatry·Liyuan LiHuafu Chen
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Aug 14, 2020·Neuroscience and Biobehavioral Reviews·Georg Northoff, Victor Lamme
Apr 14, 2021·NeuroImage·Zirui HuangAnthony G Hudetz
Jul 3, 2021·Parkinsonism & Related Disorders·Tomohito NakanoNoriaki Hattori
Nov 10, 2017·British Journal of Anaesthesia·B J A PalancaG A Mashour

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