Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder

Psychological Medicine
Rachel H JacobsScott A Langenecker

Abstract

Recent meta-analyses of resting-state networks in major depressive disorder (MDD) implicate network disruptions underlying cognitive and affective features of illness. Heterogeneity of findings to date may stem from the relative lack of data parsing clinical features of MDD such as phase of illness and the burden of multiple episodes. Resting-state functional magnetic resonance imaging data were collected from 17 active MDD and 34 remitted MDD patients, and 26 healthy controls (HCs) across two sites. Participants were medication-free and further subdivided into those with single v. multiple episodes to examine disease burden. Seed-based connectivity using the posterior cingulate cortex (PCC) seed to probe the default mode network as well as the amygdala and subgenual anterior cingulate cortex (sgACC) seeds to probe the salience network (SN) were conducted. Young adults with remitted MDD demonstrated hyperconnectivity of the left PCC to the left inferior frontal gyrus and of the left sgACC to the right ventromedial prefrontal cortex (PFC) and left hippocampus compared with HCs. Episode-independent effects were observed between the left PCC and the right dorsolateral PFC, as well as between the left amygdala and right insula and ...Continue Reading

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Citations

Jul 28, 2016·Depression and Anxiety·Natania A CraneScott A Langenecker
Oct 25, 2017·Cognitive, Affective & Behavioral Neuroscience·Jamie FerriDaniel H Mathalon
Mar 7, 2018·CNS Neuroscience & Therapeutics·Fei-Fei ZhangQi-Yong Gong
Apr 19, 2019·Journal of Neuroinflammation·Chun-Hong LiuLihong Wang
Dec 4, 2019·The American Journal of Psychiatry·Dirk ScheeleRené Hurlemann
Apr 2, 2020·International Journal of Psychiatry in Clinical Practice·Yulu SongBin Wang
Oct 11, 2019·Psychological Medicine·Jonathan P StangeScott A Langenecker
May 16, 2021·Social Cognitive and Affective Neuroscience·Leyi FanSiyang Luo
Sep 12, 2020·Journal of Medicinal Chemistry·Joydip Das

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