PMID: 9542735May 23, 1998Paper

Decoupling: theory and practice. I. Current methods and recent concepts

NMR in Biomedicine
R Freeman, E Kupce

Abstract

Current methods for broadband heteronuclear decoupling are reviewed from a historical perspective. The principal concern is that decoupling should be effective over a wide range of chemical shifts without undue radiofrequency heating of the sample, particularly when human patients are involved. Continuous-wave methods are the least efficient in this respect, followed by noise decoupling. Composite pulse schemes offer a more effective use of radiofrequency power, while adiabatic passage methods are the most efficient of all. Bi-level decoupling employs a low level of radiofrequency irradiation during the relaxation delay to maintain the nuclear Overhauser effect, with a higher level during signal acquisition in order to decouple over a wide frequency band. All decoupling sequences introduce cycling sidebands into the observed spectrum, and schemes are described to minimize the intensity of these artifacts. In part II, practical applications of decoupling methods are examined in the context of in vivo spectroscopy, where the improvements in sensitivity and resolution through broadband decoupling can be critical for solving clinical problems. Attention is focused on the regulatory limits on power deposition in these experiments. A...Continue Reading

References

Dec 1, 1985·Physical Review A: General Physics·J BaumA Pines

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Citations

Apr 15, 2004·Journal of Magnetic Resonance·Lorenz MitschangHerbert Rinneberg
Oct 6, 1999·Current Opinion in Structural Biology·G Wider, K Wüthrich
Oct 16, 2010·Marine Drugs·Haakil LeeJeffrey M Macdonald
Dec 3, 2016·Chemical Communications : Chem Comm·Pinelopi MoutzouriGareth A Morris
Oct 31, 1998·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R A de Graaf, K Nicolay
May 21, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Robin A de Graaf
Mar 30, 2016·Magnetic Resonance in Chemistry : MRC·Helena Kovacs, Ēriks Kupče
Mar 23, 2021·Journal of Biomolecular NMR·Clemens Anklin, R Andrew Byrd
Mar 22, 2021·Journal of Biomolecular NMR·Youlin XiaCharalampos G Kalodimos
Oct 31, 2017·Analytical Chemistry·Pinelopi MoutzouriGareth A Morris

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