PMID: 9542736May 23, 1998Paper

Decoupling: theory and practice. II. State of the art: in vivo applications of decoupling

NMR in Biomedicine
D M Freeman, R Hurd

Abstract

Current methods for broadband heteronuclear decoupling are reviewed from a historical perspective. The principal concern is that decoupling should be effective over a wide range of chemical shifts without undue radiofrequency heating of the sample, particularly when human patients are involved. Continuous-wave methods are the least efficient in this respect, followed by noise decoupling. Composite pulse schemes offer a more effective use of radiofrequency power, while adiabatic passage methods are the most efficient of all. Bi-level decoupling employs a low level of radiofrequency irradiation during the relaxation delay to maintain the nuclear Overhauser effect, with a higher level during signal acquisition in order to decouple over a wide frequency band. All decoupling sequences introduce cycling sidebands into the observed spectrum, and schemes are described to minimize the intensity of these artifacts. In part II, practical applications of decoupling methods are examined in the context of in vivo spectroscopy, where the improvements in sensitivity and resolution through broadband decoupling can be critical for solving clinical problems. Attention is focused on the regulatory limits on power deposition in these experiments. A...Continue Reading

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Citations

Aug 31, 2002·NMR in Biomedicine·J Eric JensenPeter C Williamson
Nov 30, 2012·Journal of Biomolecular NMR·Karin V Loscha, Gottfried Otting
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Mar 29, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Miriam W LagemaatTom W J Scheenen
Jan 30, 2007·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Shizhe LiJun Shen
Jan 30, 2007·Journal of Magnetic Resonance Imaging : JMRI·Chris Boesch
Nov 8, 2005·NMR in Biomedicine·Shizhe LiJun Shen
Apr 12, 2016·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jimin RenCraig R Malloy
Feb 11, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Alfredo L Lopez KolkovskyPierre G Carlier

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