Decoy receptor 3 suppresses TLR2-mediated B cell activation by targeting NF-κB

The Journal of Immunology : Official Journal of the American Association of Immunologists
Zi-Ming HuangChuen-Miin Leu

Abstract

Decoy receptor 3 (DcR3) is a soluble protein in the TNFR superfamily. Its known ligands include Fas ligand, homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes, TNF-like molecule 1A, and heparan sulfate proteoglycans. DcR3 has been reported to modulate the functions of T cells, dendritic cells, and macrophages; however, its role in regulating B cell activation is largely unknown. In this study, we found that the DcR3.Fc fusion protein bound to human and mouse B cells and suppressed the activation of B cells. DcR3.Fc attenuated Staphylococcus aureus, IgM-, Pam(3)CSK(4)-, and LPS-mediated B cell proliferation but did not affect cytokine-induced B cell growth. In the presence of these mitogens, DcR3.Fc did not induce B cell apoptosis, suggesting that DcR3 may inhibit the signal(s) important for B cell activation. Because the combination of Fas.Fc, LT-βR.Fc (homologous to lymphotoxin, showing inducible expression, and competing with HSV glycoprotein D for herpes virus entry mediator, a receptor expressed by T lymphocytes receptor), and DR3.Fc (TNF-like molecule 1A receptor) did not suppress B cell proliferation and beca...Continue Reading

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Citations

Jan 24, 2014·Mediators of Inflammation·Yoshihiro Aiba, Minoru Nakamura
Aug 16, 2013·Current Opinion in Allergy and Clinical Immunology·Ingo MarenholzYoung-Ae Lee
Sep 11, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Yoshihiro AibaMinoru Nakamura
Jun 21, 2017·Journal of Biomedical Science·Shie-Liang Hsieh, Wan-Wan Lin
Mar 23, 2017·Journal of the Chinese Medical Association : JCMA·Tzu-Hao LiChang-Youh Tsai

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