Decrease in Anti-HBs Antibodies over Time in Medical Students and Healthcare Workers after Hepatitis B Vaccination

BioMed Research International
H V SahanaS R Prasad

Abstract

Hepatitis B is one of the most important occupational hazards among healthcare workers (HCWs). This study aimed to measure the anti-HBs titres among the medical students and HCWs vaccinated against hepatitis B virus and to determine the association between anti-HBs levels and time since vaccination. In this cross-sectional study, medical students and healthcare workers who had received all three doses of hepatitis B vaccination and completed at least six months after vaccination since the last dose were included. 3 ml blood was collected from subjects (n = 340) and anti-HBs titre was estimated using ELISA. A total of 340/400 subjects were aged between 18 and 60 years; 204 were females and 136 males. The median and interquartile range for time since vaccination were 5 and 5 years, respectively. Duration since vaccination was ≤5 years in 223 (65.5%), 6-10 years in 84 (24.7%), and >10 years in 33 (9.70%); among them, antibody titres were >10 mIU/ml in 94.1%, 79.7%, and 72.7% subjects, respectively. There was significant decline in antibody titres as duration of postvaccination increased. The proportion of subjects who were unprotected after 5 and 10 years after vaccination were 20% and 27%, respectively. The need for a booster dos...Continue Reading

References

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Jan 18, 2006·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Luiz A S Ciorlia, Dirce M T Zanetta
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Apr 11, 2015·Jundishapur Journal of Microbiology·Roohangiz NashibiMehdi Farashahinejad

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Citations

Oct 10, 2019·Archives of Pathology & Laboratory Medicine·Dongju WonHyon-Suk Kim
Dec 28, 2019·Environmental Health and Preventive Medicine·Masanori OgawaTeppei Sasahara
Dec 14, 2018·BMC Research Notes·Claude Mambo MuvunyiThéobald Hategekimana

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Methods Mentioned

BETA
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Software Mentioned

Statistical Package for Social Sciences ( SPSS )

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