Decrease in CD4+CD25+FoxP3+ Treg cells after pulmonary resection in the treatment of cavity multidrug-resistant tuberculosis

International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases
Ying E WuKe Li

Abstract

Immune regulatory mechanisms may limit the immunopathologic condition of infection with Mycobacterium tuberculosis and suppress cellular immune responses in the host. We investigated the CD4(+)CD25(+)FoxP3(+) circulating regulatory T cells (T(reg)) in patients with cavity multidrug-resistant tuberculosis (MDR-TB) before and after surgery. We compared the proportion of T(reg) cells in 13 patients with cavity MDR-TB pre- and postoperatively and in 10 healthy control subjects by flow cytometry using three specific markers in peripheral blood lymphocytes: cell-surface CD4 and CD25 expression and intracellular FoxP3 expression. The proportion of CD4(+)CD25(high) and CD4(+)CD25(+)FoxP3(+) T(reg) was significantly higher in patients with cavity MDR-TB and at 1-month postoperatively than in healthy controls (p<0.001). The proportion of CD4(+) and CD4(+)CD25(-) cells was significantly lower in patients with cavity MDR-TB than in controls (p<0.001). Pre- and postoperative proportions of CD4(+)CD25(high) and CD4(+)CD25(+)FoxP3(+) T(reg) cells showed a positive correlation (r=0.878, p<0.001). Circulating T(reg) cells are increased in proportion in patients with cavity MDR-TB and decreased after surgery. Infection with M. tuberculosis may i...Continue Reading

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Citations

Apr 25, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·Qin SunBo Su
Jun 19, 2014·American Journal of Respiratory and Critical Care Medicine·Jan HeyckendorfChristoph Lange
Jul 12, 2014·Revue des maladies respiratoires·P MordantF Le Pimpec-Barthes
May 8, 2015·Immunologic Research·Om ParkashM Madhan Kumar
Apr 19, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·XueXuan ZhangYingE Wu
Sep 14, 2019·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Majid Faridgohar
Mar 1, 2014·Emerging Microbes & Infections·Anastasia KochDigby F Warner
Jan 15, 2017·Microbiology Spectrum·Susanna Brighenti, Diane J Ordway

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