Decrease in circulating endothelial progenitor cells in treated glioma patients.

Journal of Neuro-oncology
Elena CorsiniAndrea Salmaggi

Abstract

High-grade gliomas are highly vascularized tumors, in which the amount of new blood vessels is closely related with the degree of malignancy. The role of endothelial progenitor cells (EPCs) in the neoangiogenesis of gliomas and the effects of post-surgical therapies (i.e., radiotherapy (RT) and chemotherapy) have not yet been fully elucidated. The aim of the present study was to evaluate the effect of surgery and post-surgical treatment on the levels of circulating EPCs in glioma patients and their correlation with vascular endothelial growth factor (VEGF). In this study, we assessed by flow cytometry the number of EPCs in the peripheral blood of 78 high-grade glioma patients (both untreated and treated with RT and chemotherapy) and 34 age- and sex-matched healthy controls. EPCs were markedly decreased in all treated glioma patients as compared to untreated ones. VEGF levels were significantly higher in patients as compared to controls, and surgery, but not chemotherapy, significantly decreased VEGF concentrations. We found no relationship between VEGF plasma levels and EPCs. In conclusion, the reliability of EPCs as a biomarker for monitoring angiogenesis in glioma patients needs further studies of correlations of this paramet...Continue Reading

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Citations

Sep 24, 2015·Expert Review of Molecular Diagnostics·Mehdi TouatAhmed Idbaih
Jul 14, 2012·Journal of Neuro-oncology·George A AlexiouSpyridon Voulgaris
Apr 4, 2013·Biomarkers in Medicine·Aysegül Ilhan-MutluMatthias Preusser
Sep 23, 2014·Future Oncology·Cristiana TanaseMonica Neagu
Feb 28, 2015·Acta Neuropathologica·Myron G BestThomas Wurdinger
Jan 4, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Anna BersanoUNKNOWN GEN-O-MA study group
Aug 17, 2020·International Journal of Molecular Sciences·Francesca TinelliLaura Gatti
Jun 22, 2021·Frontiers in Oncology·Hamza AliMyron G Best

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