Decrease in circulating tryptophan availability to the brain after acute ethanol consumption by normal volunteers: implications for alcohol-induced aggressive behaviour and depression

Pharmacopsychiatry
Abdulla A-B BadawyR Thomas

Abstract

Acute ethanol consumption by fasting male volunteers decreases circulating trytophan (Trp) concentration and availability to the brain as determined by the ratio of (Trp) to the sum of its five competitors ([Trp]/[CAA]ratio). These effects of alcohol are specific to Trp, because levels of the 5 competitors are not increased. The decrease in circulating (Trp) is not associated with altered binding to albumin and may therefore be due to enhancement of hepatic Trp pyrrolase activity. It is suggested that, under these conditions brain serotonin synthesis is likely to be impaired and that, as a consequence, a possible strong depletion of brain serotonin in susceptible individuals may induce aggressive behaviour after alcohol consumption. The possible implications of these findings in the relationship between alcohol and depression are also briefly discussed.

Citations

Feb 10, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdulla A-B BadawyAlex Steptoe
Mar 15, 2014·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Abdulla A-B Badawy
Apr 22, 2008·Cellular and Molecular Neurobiology·K G AkashC S Paulose
Mar 8, 2016·Oxidative Medicine and Cellular Longevity·José A HernándezAdela Rendón-Ramírez
Nov 19, 2003·Criminal Behaviour and Mental Health : CBMH·Abdulla A-B Badawy
Feb 3, 2009·Alcoholism, Clinical and Experimental Research·Michael S McCloskeyEmil F Coccaro
Dec 17, 2008·Journal of Psychopharmacology·A A-B Badawy
Jun 1, 2002·Nutrition Research Reviews·Abdulla A-B Badawy
Mar 23, 2007·Psychopharmacology·Donald M DoughertyAbdulla A-B Badawy
Jan 1, 2010·International Journal of Tryptophan Research : IJTR·Donald M DoughertyCharles W Mathias
Oct 24, 2007·Psychopharmacology·Elizabeth E Caldwell, Klaus A Miczek
Jan 1, 2005·Professional Psychology, Research and Practice·Susan E RamseyMichael D Stein
Sep 18, 2009·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Jean VignauDelphine Allorge
Mar 31, 2019·The International Journal of Neuropsychopharmacology·Louisa J SteinbergJ John Mann
Aug 8, 2006·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·John Brady
May 17, 2007·American Journal of Physiology. Endocrinology and Metabolism·Saman AbeysekaraGordon A Zello
Mar 17, 1999·The American Journal of Drug and Alcohol Abuse·J M BjorkF G Moeller
Apr 6, 2013·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Marion SoichotDelphine Allorge
Mar 23, 2009·International Journal of Tryptophan Research : IJTR·Dawn M RichardDonald M Dougherty
May 4, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Rebeca VidalFrancisco Javier Pavón
May 25, 2021·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Frantz PierreKaku So-Armah

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.