Decrease in Expression of HOXA10 in the Decidua After Embryo Implantation Promotes Trophoblast Invasion

Endocrinology
Geeta GodboleDeepak Modi

Abstract

An important step toward successful pregnancy involves invasion of the trophoblast cells into the decidua for placentation. Herein, we show that in the human and baboon decidua HOXA10 expression is downregulated after implantation and that this reduction is most prominent in the decidual cells juxtaposed to the invading placental villi. The supernatants derived from HOXA10-depleted human decidual cells increase the invasiveness of the trophoblast cell lines ACH-3P and JEG3 in vitro; this increase is due to higher expression and activity of matrix metalloproteases (MMPs) and reduced expression of tissue inhibitors of MMPs in both the cell lines. The proinvasive ability of HOXA10-depleted decidual cells is due to increased levels and secretion of leukemia inhibitor factor (LIF) and interleukin (IL)-6. Both these cytokines individually promote invasion of ACH-3P and JEG3 cell by increasing the activities of MMPs and decreasing mRNA levels of TIMPs. Finally, we demonstrate that the supernatants derived from HOXA10-depleted decidual cell-phosphorylated STAT3 (Tyr 705) and knocking down STAT3 in ACH-3P and JEG3 cells restrained the invasion mediated by supernatants derived from HOXA10-depleted decidual cells. These results imply that...Continue Reading

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Citations

Aug 6, 2018·Journal of Cellular Physiology·Priyanka BanerjeeSatish Kumar Gupta
Oct 27, 2018·Journal of Assisted Reproduction and Genetics·Noble K Kurian, Deepak Modi
Jan 11, 2018·Endocrinology·Nancy AsharyDeepak Modi
Mar 30, 2018·Reproductive Sciences·Yasaman SamadiehMaryam Shahhoseini
Jul 17, 2018·Biology of Reproduction·Koji Yoshinaga
Apr 23, 2020·International Journal of Molecular Medicine·Lu ZhangShuquan Zhang
Dec 20, 2019·Acta Biochimica Et Biophysica Sinica·Yifei SangMeirong Du
Jul 4, 2018·Journal of Assisted Reproduction and Genetics·Saniya LaheriDeepak Modi
Nov 18, 2020·Journal of Cellular and Molecular Medicine·Yao XiongYuanzhen Zhang
Oct 17, 2020·American Journal of Reproductive Immunology : AJRI·Anuradha MishraDeepak Modi
Mar 9, 2021·Theriogenology·Uğur Topaloğlu, Muzaffer Aydın Ketani

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