Decrease in expression of maternal effect gene Mater is associated with maternal ageing in mice

Molecular Human Reproduction
Yong-qing LuPing Zheng

Abstract

What factors in mouse oocytes are involved in the ageing-related decline in oocyte quality? The maternal effect gene Mater is involved in ageing-related oocyte quality decline in mice. Premature loss of centromere cohesion is a hallmark of ageing-related oocyte quality decline; the maternal effect gene Mater (maternal antigen that embryos require, also known as Nlrp5) is required for preimplantation embryo development beyond the 2-cell stage, and mRNA expression of Mater decreases with maternal ageing. Mater protein expression level in mature oocytes from 7 young (5-8 weeks old) to 7 old mice (41-68 weeks old) was compared by immunoblotting analysis. Wild-type and Mater-null mice were used to examine whether Mater is necessary for maintaining normal centromere cohesion by means of cytogenetic karyotyping, time-lapse confocal microscopy and immunofluorescence staining. Mater protein is decreased in mature oocytes from old versus young mice (P = 0.0022). Depletion of Mater from oocytes leads to a reduction in centromere cohesion, manifested by precocious sister chromatid separation, enlargement of sister centromere distance and misalignment of chromosomes in the metaphase plate during meiosis I and II. This study was conducted in...Continue Reading

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Aug 16, 2016·Journal of Assisted Reproduction and Genetics·D BebbereS Ledda
Jun 16, 2019·Biology of Reproduction·Mahboobeh AmoushahiKarin Lykke-Hartmann
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Jul 3, 2020·Journal of Assisted Reproduction and Genetics·D BebbereS Ledda
Jul 1, 2021·Molecular Human Reproduction·Daniela BebbereSergio Ledda

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